2-Methoxy-6-nitrobenzoyl chloride

Base Information

• Chemical Name: 2-Methoxy-6-nitrobenzoyl chloride
• CAS No.: 33844-24-5
• Molecular Formula: C8H6ClNO4
• Molecular Weight: 215.593
• DSSTox Substance ID: DTXSID301300296
• Mol file: 33844-24-5.mol

Synonyms:2-Methoxy-6-nitrobenzoyl chloride;33844-24-5;SCHEMBL8579895;DTXSID301300296

Chemical Property of 2-Methoxy-6-nitrobenzoyl chloride

Chemical Property:

• PSA: 72.12000
• LogP: 2.50560
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 214.9985354
• Heavy Atom Count: 14
• Complexity: 240

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxy-6-nitrobenzoylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1C(=O)Cl)[N+](=O)[O-]

Technology Process of 2-Methoxy-6-nitrobenzoyl chloride

There total 3 articles about 2-Methoxy-6-nitrobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-6-methoxybenzoic acid (53967-73-0) → 2-methoxy-6-nitro-benzoyl chloride (33844-24-5)

Guidance literature:

With thionyl chloride;

DOI:10.1021/jo01179a003

Reference yield:

2-chloromethyl-3-nitro-anisole (64208-72-6) → 2-methoxy-6-nitro-benzoyl chloride (33844-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate; aqueous KOH-solution

2: thionyl chloride

With potassium hydroxide; potassium permanganate; thionyl chloride;

DOI:10.1021/jo01179a003

Reference yield:

→ 2-methoxy-6-nitro-benzoyl chloride (33844-24-5)

Guidance literature:

entspr. Saeure, SOCl2;

upstream raw materials:

2-nitro-6-methoxybenzoic acid

2-chloromethyl-3-nitro-anisole

Downstream raw materials:

2-diazo-1-(2-methoxy-6-nitro-phenyl)-ethanone

1-(2-methoxy-6-nitro-benzoyl)-1,2-dihydro-quinoline-2-carbonitrile

N,N'-bis-(2-methoxy-6-nitro-benzoyl)-hydrazine

1-(2-methoxy-6-nitro-phenyl)-ethanone