Benzene, 2-(chloromethyl)-1-methoxy-3-nitro-

Base Information

• Chemical Name: Benzene, 2-(chloromethyl)-1-methoxy-3-nitro-
• CAS No.: 64208-72-6
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.609
• Mol file: 64208-72-6.mol

Synonyms:α-Chlor-6-nitro-2-methoxy-toluol;6-Nitro-2-methoxy-benzylchlorid;2-Chlormethyl-3-nitro-anisol;Methyl-(3-nitro-2-chlormethyl-phenyl)-aether;6-Nitro-2-methoxy-1-chlormethyl-benzol;

Chemical Property of Benzene, 2-(chloromethyl)-1-methoxy-3-nitro-

Chemical Property:

• PSA: 55.05000
• LogP: 2.86540

Purity/Quality:

98.5% ^*data from raw suppliers

2-Methoxy-6-nitrobenzylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 2-(chloromethyl)-1-methoxy-3-nitro-

There total 4 articles about Benzene, 2-(chloromethyl)-1-methoxy-3-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-nitrophenol (554-84-7) → 2-chloromethyl-3-nitro-anisole (64208-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated aqueous HCl / Einleiten von HCl bei 37-38grad

2: diethyl ether

With hydrogenchloride; diethyl ether;

DOI:10.2165/00002018-200124100-00004

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-chloromethyl-3-nitro-phenol (855157-00-5) → 2-chloromethyl-3-nitro-anisole (64208-72-6)

Guidance literature:

With diethyl ether;

DOI:10.2165/00002018-200124100-00004

Reference yield:

(2-methoxy-6-nitrophenyl)methanol (19689-87-3) → 2-chloromethyl-3-nitro-anisole (64208-72-6)

Guidance literature:

With thionyl chloride;

upstream raw materials:

diazomethane

2-chloromethyl-3-nitro-phenol

(2-methoxy-6-nitrophenyl)methanol

meta-nitrophenol

Downstream raw materials:

2-methoxy-6-nitro-benzoyl chloride

2-(2-methoxy-6-nitrophenyl)acetic acid

4-methoxy-1-methyloxindole

4-methoxyindolin-2-one