53967-73-0

Basic information

• Product Name: 2-Methoxy-6-nitrobenzoic Acid
• Synonyms: 2-Nitro-6-Methoxybenzoic acid;6-Nitro-o-anisic acid
• CAS NO: 53967-73-0
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.15
• Product Categories: Acids and Derivatives
• Mol File: 53967-73-0.mol

Chemical Properties

• Melting Point: 180℃
• Boiling Point: 374.6 °C at 760 mmHg
• Flash Point: 180.3 °C
• Appearance: /
• Density: 1.430
• Vapor Pressure: 2.82E-06mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.90±0.30(Predicted)
• CAS DataBase Reference: 2-Methoxy-6-nitrobenzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-6-nitrobenzoic Acid(53967-73-0)
• EPA Substance Registry System: 2-Methoxy-6-nitrobenzoic Acid(53967-73-0)

Safety Data

• Hazardous Substances Data: 53967-73-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-6-nitrobenzoic Acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Dye Industry:
In the dye industry, 2-Methoxy-6-nitrobenzoic Acid is utilized as a precursor for the production of various dyes. Its chemical properties enable the creation of a wide range of colors and hues, making it a valuable component in the formulation of dyes for textiles, plastics, and other materials.
Used in Organic Chemistry Research:
2-Methoxy-6-nitrobenzoic Acid serves as a valuable research tool in organic chemistry. Its reactivity and functional groups make it an ideal candidate for studying various chemical reactions and mechanisms, contributing to the advancement of scientific knowledge and the development of new synthetic methods.
Used in Synthesis of Other Organic Compounds:
Beyond its applications in pharmaceuticals and dyes, 2-Methoxy-6-nitrobenzoic Acid is also used in the synthesis of other organic compounds. Its versatile chemical structure allows it to be a building block for the creation of a variety of molecules with different properties and applications, further expanding its utility in the field of organic chemistry.

InChI:InChI=1/C8H7NO5/c1-14-6-4-2-3-5(9(12)13)7(6)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 4837-88-1 6-methoxy-2-nitrotoluene 
• 64431-77-2 2-methoxy-6-nitro-benzoic acid amide 
• 64208-72-6 2-chloromethyl-3-nitro-anisole 
• 855157-00-5 2-chloromethyl-3-nitro-phenol 
• 5460-31-1 3-nitro-o-cresol 
• 19689-88-4 2-methoxy-6-nitrobenzaldehyde 
• 601-99-0 2-hydroxy-6-nitrobenzoic acid 
• 77-78-1 dimethyl sulfate 
• 861306-00-5 3-amino-2-methoxy-6-nitro-benzoic acid 

Downstream Products

• 77901-52-1 methyl 2-methoxy-6-nitrobenzoate 
• 99060-89-6 2-methoxy-6-nitro-benzoic acid ethyl ester 
• 53600-33-2 6-methoxyanthranilic acid 
• 33844-24-5 2-methoxy-6-nitro-benzoyl chloride 
• 19689-87-3 (2-methoxy-6-nitrophenyl)methanol 
• 555-03-3 3-nitroanisole 
• 86434-31-3 1-Benzenesulfonylmethyl-4-methoxy-2-nitro-benzene 
• 86434-27-7 1-Benzenesulfonylmethyl-2-methoxy-4-nitro-benzene 
• 86434-34-6 2-Benzenesulfonylmethyl-1-methoxy-3-nitro-benzene 
• 98488-49-4 2-methoxy-6-nitro-benzoic acid hydrazide 
• 101352-42-5 N,N'-bis-(2-methoxy-6-nitro-benzoyl)-hydrazine 
• 19532-68-4 2,2'-dithiobis(6-methoxybenzoic acid) 
• 33844-23-4 1-(2-amino-6-methoxyphenyl)ethanone 
• 1429782-09-1 C₁₁H₁₀Cl₃NO₃ 

Relevant articles and documents

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Since the discovery of HIV as the etiological agent of AIDS, the virus has infected millions of people each year. Fortunately, with the use of HAART, viremia can be suppressed to below detectable levels in the infected individuals, which significantly improves their quality of life and prevents the onset of AIDS. However, HAART is not curative and issues relating to adherence and drug resistance may lead to the re-emergence of viremia, the development of AIDS, and ultimately death. To address a pressing need for the development of new and efficacious antiretroviral agents with activity against viruses bearing prevalent resistant mutations, we have designed two generations of benzimidazolone derivatives as HIV non-nucleoside reverse transcriptase inhibitors. The first generation benzimidazolone inhibitors were found to be potent inhibitors of wild-type HIV reverse transcriptase but were ineffective in the presence of common resistance mutations such as K103N and Y181C. A second generation benzimidazolone inhibitor (compound 42) not only showed inhibitory activity against wild-type HIV but also remained active against HIV containing the K103N, Y181C, and K103N/Y181C drug resistance mutations.

Effect of aldehyde and methoxy substituents on nucleophilic aromatic substitution by [18F]fluoride

For a series of benzaldehydes only with a leaving group or with both a leaving group and a single methoxy substituent 18F-fluorination via nucleophilic aromatic substitution (SNAr) was studied in DMF and Me2SO. In general, the radiochemical yields were clearly higher in DMF than in Me2SO. In the fluorodehalogenation reaction (leaving group: halogen = Br, Cl), extremely low radiochemical yields were observed in Me2SO (2SO (within 3 min reaction time, 90% of the precursor was consumed; radiochemical yield = 1.0 ± 0.5%); however, in DMF oxidation was always kept at a low level during the entire reaction (13C-NMR ppm values of the aromatic carbon atom bearing the leaving group.