2,3-Dimethoxy-2'-hydroxychalcone

Base Information

• Chemical Name: 2,3-Dimethoxy-2'-hydroxychalcone
• CAS No.: 34000-33-4
• Molecular Formula: C17H16O4
• Molecular Weight: 284.312
• UNII: VJF3CDH5PW
• Nikkaji Number: J2.048.097A,J2.305.563E
• Metabolomics Workbench ID: 73711
• ChEMBL ID: CHEMBL492959
• Mol file: 34000-33-4.mol

Synonyms:2,3-dimethoxy-2'-hydroxychalcone;42220-80-4;2'-HYDROXY-2,3-DIMETHOXYCHALCONE;CHEMBL492959;(E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one;D0LB6L;SCHEMBL5084423;HKKXNGSRSNONCJ-ZHACJKMWSA-N;2,3-dimethoxy-2''-hydroxychalcone;(2E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one;BDBM50257725;MFCD00016444;AKOS024287245;(E)-2'-Hydroxy-2,3-dimethoxychalcone;PD180134;2,3-Dimethoxy-2'-hydroxychalcone, AldrichCPR;2-Propen-1-one, 3-(2,3-dimethoxyphenyl)-1-(2-hydroxyphenyl)-

Chemical Property of 2,3-Dimethoxy-2'-hydroxychalcone

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 284.10485899
• Heavy Atom Count: 21
• Complexity: 366

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)C=CC(=O)C2=CC=CC=C2O
• Isomeric SMILES: COC1=CC=CC(=C1OC)/C=C/C(=O)C2=CC=CC=C2O

Technology Process of 2,3-Dimethoxy-2'-hydroxychalcone

There total 2 articles about 2,3-Dimethoxy-2'-hydroxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ (E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (34000-33-4,42220-80-4)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃;

Reference yield: 59.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) + 2,3-dimethyoxybenzaldehyde (86-51-1) → (E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (34000-33-4,42220-80-4)

Guidance literature:

With potassium hydroxide; In ethanol; water;

DOI:10.1080/00397910802372517

Reference yield: 42.0%

(E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (34000-33-4,42220-80-4) + 1,2-diamino-benzene (95-54-5) → 2-(2,3-dimethoxyphenyl)-4-(2-hydroxyphenyl)-2,3-dihydro-1H-1,5-benzodiazepine (1030592-46-1)

Guidance literature:

With aluminum oxide; for 0.5h; Microwave irradiation;

DOI:10.1080/00397910802372517

upstream raw materials:

o-hydroxyacetophenone

2,3-dimethyoxybenzaldehyde

Downstream raw materials:

(Z)-2(2,3-dimethoxybenzylidene)benzofuran-3(2H)-one

2',3'-Dimethoxyflavone

2,3-dihydro-2-(2,3-dimethoxyphenyl)chromen-4-one

2-(2,3-dimethoxyphenyl)-4-(2-hydroxyphenyl)-2,3-dihydro-1H-1,5-benzodiazepine