5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-phenyl-2-thioxo-6-(trifluoromethyl)-, ethyl ester

Base Information

Chemical Name:5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-phenyl-2-thioxo-6-(trifluoromethyl)-, ethyl ester
CAS No.:340-72-7
Molecular Formula:C14H13F3N2O2S
Molecular Weight:330.32500
Hs Code.:

Synonyms:4-phenyl-2-thioxo-6-trifluoromethyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester;4-Phenyl-2-thioxo-6-trifluormethyl-1,2,3,4-tetrahydro-pyrimidin-5-carbonsaeure-aethylester;

Suppliers and Price of 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-phenyl-2-thioxo-6-(trifluoromethyl)-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-phenyl-2-thioxo-6-(trifluoromethyl)-, ethyl ester

Chemical Property:

Melting Point:183 °C (benzene)
PSA：82.45000
LogP:3.24250

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-phenyl-2-thioxo-6-(trifluoromethyl)-, ethyl ester

There total 5 articles about 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-phenyl-2-thioxo-6-(trifluoromethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 100-52-7
benzaldehyde

: 17356-08-0
thiourea

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 340-72-7
5-Ethoxycarbonyl-6-trifluoromethyl-4-phenyl-3,4-dihydropyrimidine-2(1H)-thione

Guidance literature:: With tantalum pentabromide; at 70 - 80 ℃; for 0.75h;
DOI:10.1016/j.tetlet.2007.06.005

Reference yield: 45.0%

: 113697-54-4
Ethyl β-aryl-α-trifluoroacetyl-β-thioureidopropionates

: 340-72-7
5-Ethoxycarbonyl-6-trifluoromethyl-4-phenyl-3,4-dihydropyrimidine-2(1H)-thione

Guidance literature:: With PPA; for 8h; Heating;

Reference yield:

: 100-52-7
benzaldehyde

: 340-72-7
5-Ethoxycarbonyl-6-trifluoromethyl-4-phenyl-3,4-dihydropyrimidine-2(1H)-thione

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / HCl / methanol; H₂O / 48 h / 20 °C

2: 45 percent / polyphosphoric acid / 8 h / Heating

With hydrogenchloride; PPA; In methanol; water;