5-chloro-N-(4-fluorophenyl)-2-hydroxybenzamide

Base Information

• Chemical Name: 5-chloro-N-(4-fluorophenyl)-2-hydroxybenzamide
• CAS No.: 343-60-2
• Molecular Formula: C13H9ClFNO2
• Molecular Weight: 265.671
• DSSTox Substance ID: DTXSID501247367
• Pharos Ligand ID: DZPNPCTB784L
• ChEMBL ID: CHEMBL2312822
• Mol file: 343-60-2.mol

Synonyms:5-chloro-N-(4-fluorophenyl)-2-hydroxybenzamide;343-60-2;CHEMBL2312822;SCHEMBL18341391;DTXSID501247367;BDBM50540433;AKOS008973377;5-chloro-N-(4-fluorophenyl)-2-hydroxy-benzamide;AI-204/12793025;benzamide,5-chloro-n-(4-fluorophenyl)-2-hydroxy-;Benzamide, 5-chloro-N-(4-fluorophenyl)-2-hydroxy-;Z68090552

Chemical Property of 5-chloro-N-(4-fluorophenyl)-2-hydroxybenzamide

Chemical Property:

• Melting Point: 239 - 240 °C
• PSA: 49.33000
• LogP: 3.51000
• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 265.0305844
• Heavy Atom Count: 18
• Complexity: 295

Purity/Quality:

95% ^*data from raw suppliers

5-CHLORO-N-(4-FLUOROPHENYL)-2-HYDROXY-BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Cl)O)F

Technology Process of 5-chloro-N-(4-fluorophenyl)-2-hydroxybenzamide

There total 4 articles about 5-chloro-N-(4-fluorophenyl)-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

5-chloro-2-hydroxybenzoic acid (321-14-2) + 4-fluoroaniline (371-40-4) → 5-chloro-N-(4'-fluorophenyl)-2-hydroxybenzamide (343-60-2)

Guidance literature:

5-chloro-2-hydroxybenzoic acid; 4-fluoroaniline; In 5,5-dimethyl-1,3-cyclohexadiene; at 120 ℃; for 0.5h;

With phosphorus trichloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 120 ℃; for 3h;

DOI:10.1007/s00044-021-02808-4

Reference yield: 8.0%

5-chloro-2-hydroxybenzoic acid (321-14-2) + 4-fluoroaniline (371-40-4) → 5-chloro-N-(4'-fluorophenyl)-2-hydroxybenzamide (343-60-2)

Guidance literature:

With pyridine; phosphorus trichloride; In toluene; for 12h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2012.10.056

Reference yield:

5-chloro-2-hydroxybenzoyl chloride (15216-81-6) + 4-fluoroaniline (371-40-4) → 5-chloro-N-(4'-fluorophenyl)-2-hydroxybenzamide (343-60-2)

Guidance literature:

With pyridine; at 90 ℃; for 2h;

DOI:10.1016/j.bmcl.2021.127906

upstream raw materials:

5-chloro-2-hydroxybenzoic acid

4-fluoroaniline

5-chloro-2-hydroxybenzoyl chloride

Downstream raw materials:

4-chloro-2-(4-fluorophenylcarbamoyl)phenyl 4-(trifluoromethyl)benzoate

4-chloro-2-[(4-fluorophenyl)carbamoyl]phenyl diethyl phosphate

C₂₀H₁₃ClFNO₃

4-chloro-2-(4-fluorophenylcarbamoyl)phenyl pyrazine-2-carboxylate