1-Benzyl-2-ethoxycarbonyl-5-methoxyindole

Base Information

Chemical Name:1-Benzyl-2-ethoxycarbonyl-5-methoxyindole
CAS No.:34572-05-9
Molecular Formula:C19H19NO3
Molecular Weight:309.365
Hs Code.:
DSSTox Substance ID:DTXSID20535405
Wikidata:Q82409703

Synonyms:1-benzyl-2-ethoxycarbonyl-5-methoxyindole;34572-05-9;SCHEMBL9622481;DTXSID20535405;CDUZGZVADRTQMT-UHFFFAOYSA-N;Ethyl 1-benzyl-5-methoxy-1H-indole-2-carboxylate;5-methoxy-1-phenylmethyl-1H-indole-2-carboxylic acid, ethyl ester

Suppliers and Price of 1-Benzyl-2-ethoxycarbonyl-5-methoxyindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Benzyl-2-ethoxycarbonyl-5-methoxyindole

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:309.13649347
Heavy Atom Count:23
Complexity:394

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CC2=C(N1CC3=CC=CC=C3)C=CC(=C2)OC

Technology Process of 1-Benzyl-2-ethoxycarbonyl-5-methoxyindole

There total 4 articles about 1-Benzyl-2-ethoxycarbonyl-5-methoxyindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 4792-58-9
ethyl 5-methoxy-1H-indole-2-carboxylate

: 100-39-0
benzyl bromide

: 34572-05-9
5-methoxy-1-phenylmethyl-1H-indole-2-carboxylic acid,ethyl ester

Guidance literature:: ethyl 5-methoxy-1H-indole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.3390/ph14121289

Reference yield:

: 4382-54-1
5-methoxy-1H-indole-2-carboxylic acid

: 34572-05-9
5-methoxy-1-phenylmethyl-1H-indole-2-carboxylic acid,ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / 16 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;
DOI:10.3390/ph14121289

Reference yield:

: 4792-58-9
ethyl 5-methoxy-1H-indole-2-carboxylate

: 100-44-7
benzyl chloride

: 34572-05-9
5-methoxy-1-phenylmethyl-1H-indole-2-carboxylic acid,ethyl ester

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMSO, 50 deg C, 30 min, 2.) 80 deg C, 30 min;
DOI:10.1055/s-1984-30952