2,4-Dihydroxy-3,5,6-trimethylbenzoic acid methyl ester

Base Information

• Chemical Name: 2,4-Dihydroxy-3,5,6-trimethylbenzoic acid methyl ester
• CAS No.: 34874-78-7
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Mol file: 34874-78-7.mol

Synonyms:Methyl-2,4-dihydroxy-3,5,6-trimethylbenzoat;dihydroxy-2,4-trimethyl-3,5,6-benzoate de methyle;Benzoic acid,2,4-dihydroxy-3,5,6-trimethyl-,methyl ester;

Chemical Property of 2,4-Dihydroxy-3,5,6-trimethylbenzoic acid methyl ester

Chemical Property:

• Boiling Point: 376.7±37.0 °C(Predicted)
• PKA: 8.98±0.33(Predicted)
• PSA: 66.76000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 1.80960

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dihydroxy-3,5,6-trimethylbenzoic acid methyl ester

There total 10 articles about 2,4-Dihydroxy-3,5,6-trimethylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

formyl-3-dihydroxy-4,6-dimethyl-2,5-benzoate de methyle (34874-76-5) → 2,4-dihydroxy-3,5,6-trimethylbenzoic acid methylester (34874-78-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1002/hlca.19850680720

Reference yield:

2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester (4707-47-5) → 2,4-dihydroxy-3,5,6-trimethylbenzoic acid methylester (34874-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) trifluoroacetic acid 2.) H₂O / 1.) reflux, 12 h; 2.) 60 deg C, 6 h

2: 96 percent / hydrogen / Pd/C / ethyl acetate

With water; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In ethyl acetate;

DOI:10.1002/hlca.19850680720

Reference yield:

2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester (4707-47-5) → 2,4-dihydroxy-3,5,6-trimethylbenzoic acid methylester (34874-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / (formylation)

2: Zn, HgCl₂, aq. HCl / ethanol

With hydrogenchloride; aluminium trichloride; mercury dichloride; zinc; In ethanol;

upstream raw materials:

formyl-3-dihydroxy-4,6-dimethyl-2,5-benzoate de methyle

pseudocyphellarine B

pseudocyphellarine A

tert-butyl alcohol

Downstream raw materials:

methyl 4-benzyloxy-2-hydroxy-3,5,6-trimethylbenzoate

methyl 2-O-benzyl-4-O-methyleriodermate

pseudocyphellarine A

isopseudocyphellarin A