Chemical Property of Almotriptan malate
Chemical Property:
- Appearance/Colour:Pale yellow solid
- Vapor Pressure:1.13E-11mmHg at 25°C
- Melting Point:170-172 °C
- Boiling Point:538.7 °C at 760 mmHg
- Flash Point:279.6 °C
- PSA：159.62000
- Density:1.27g/cm3
- LogP:2.12290
- Storage Temp.:-20°C Freezer
- Solubility.:Basic Alcohol (Very Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:9
- Exact Mass:469.18827151
- Heavy Atom Count:32
- Complexity:612
- Purity/Quality:
-
99%min, *data from raw suppliers
Almotriptan Malate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3.C(C(C(=O)O)O)C(=O)O
- Recent ClinicalTrials:A 1-year Study in Adolescents to Assess the Long-term Safety of Almotriptan Malate When Treating Their Migraine Headaches
- Recent EU Clinical Trials:Treatment of Acute Migraine when Pain is Mild versus when Pain is Moderate to Severe: an Almotriptan Parallel, Placebo Controlled Clinical Trial “Act when mild?”
-
Description
Almotriptan is a kind of triptan drug which can be used for the
treatment of migraine headaches. It is belong to a drug category of
selective serotonin receptor agonists. It has a high and specificity
affinity for serotonin 5-HT receptors, further leading to
vascoconstriction of the brain blood vessel and affecting the
redistribution of blood flow. These effects stop pain signals from
being sent to the brain, and further suppressing the release of
certain natural substances which cause pain, nausea and other
migraine symptoms. However, it doesn’t prevent migraine attacks. Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay). It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate. Formulations containing almotriptan have been used in the treatment of migraine headaches.
-
Uses
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine. Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine. anti-migraine agent
-
Therapeutic Function
Migraine therapy
