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CAS No.: | 181183-52-8 |
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Name: | ALMOTRIPTAN |
Article Data: | 7 |
Molecular Structure: | |
Formula: | C21H31N3O7S |
Molecular Weight: | 469.559 |
Synonyms: | Butanedioic acid, hydroxy-, compd. with 1-(((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)pyrrolidine (1:1);Axert;1-(((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)pyrrolidine, hydroxybutanedionate (1:1);N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine; 2-hydroxybutanedioic acid; |
EINECS: | 815-382-1 |
Density: | 1.27g/cm3 |
Melting Point: | 170-172 °C |
Boiling Point: | 538.7 °C at 760 mmHg |
Flash Point: | 279.6 °C |
Appearance: | Pale yellow solid |
PSA: | 159.62000 |
LogP: | 2.12290 |
Conditions | Yield |
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In methanol for 1h; Product distribution / selectivity; Reflux; | 99.51% |
In methanol at 40℃; | 93% |
In methanol at 20 - 40℃; for 2h; Large scale; | 93% |
Conditions | Yield |
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Stage #1: almotriptan 2-hydroxy benzoate With ammonia In methanol; water; ethyl acetate for 1h; Stage #2: malic acid In methanol at 25℃; for 4.5h; Product distribution / selectivity; Heating / reflux; | |
Stage #1: almotriptan 2-hydroxy benzoate With ammonia In water; ethyl acetate at 25 - 30℃; for 1h; Stage #2: malic acid In methanol at 25 - 30℃; for 4.5h; Product distribution / selectivity; Heating / reflux; |
N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonyl-methyl)-1H-indol-3-yl]-ethanaminium semioxalate
malic acid
almotriptan malate
Conditions | Yield |
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Stage #1: N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonyl-methyl)-1H-indol-3-yl]-ethanaminium semioxalate With ammonia In water; ethyl acetate for 1h; Stage #2: malic acid In methanol at 20℃; for 4.5h; Product distribution / selectivity; Heating / reflux; | |
Stage #1: N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonyl-methyl)-1H-indol-3-yl]-ethanaminium semioxalate With ammonia In water; ethyl acetate for 1h; Stage #2: malic acid In methanol at 25 - 35℃; for 4.5h; Product distribution / selectivity; Heating / reflux; |