2-(4-chlorophenyl)-4-(ethoxymethylene)-1,3-oxazol-5(4H)-one

Base Information

• Chemical Name: 2-(4-chlorophenyl)-4-(ethoxymethylene)-1,3-oxazol-5(4H)-one
• CAS No.: 353280-77-0
• Molecular Formula: C12H10ClNO3
• Molecular Weight: 251.669
• Mol file: 353280-77-0.mol

Synonyms:4-ethoxymethylene-2-(4-chloro-phenyl)-4H-oxazol-5-one;2-(4-Chloro-phenyl)-4-[1-ethoxy-meth-(Z)-ylidene]-4H-oxazol-5-one;2-(p-Chlorphenyl)-4-aethoxymethylen-oxazolon-(5);4-ethoxymethylene-2-p-chlorophenyl-5-azlactone;4-Aethoxymethylen-2-(4-chlor-phenyl)-4H-oxazol-5-on;

Chemical Property of 2-(4-chlorophenyl)-4-(ethoxymethylene)-1,3-oxazol-5(4H)-one

Chemical Property:

• Melting Point: 195 °C
• PSA: 47.89000
• LogP: 1.95690

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-4-(ethoxymethylene)-1,3-oxazol-5(4H)-one

There total 2 articles about 2-(4-chlorophenyl)-4-(ethoxymethylene)-1,3-oxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorohippuric acid (13450-77-6) + orthoformic acid triethyl ester (122-51-0) → 2-(4-chloro-phenyl)-4-ethoxymethylene-4H-oxazol-5-one (353280-77-0)

Guidance literature:

With acetic anhydride;

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → 2-(4-chloro-phenyl)-4-ethoxymethylene-4H-oxazol-5-one (353280-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 23 °C

2: Ac₂O / 95 °C

With sodium hydroxide; acetic anhydride;

DOI:10.1016/j.bmcl.2003.10.032

Reference yield: 96.0%

C13H18N2O2 (777047-83-3) + 2-(4-chloro-phenyl)-4-ethoxymethylene-4H-oxazol-5-one (353280-77-0) → 5-(p-chlorobenzoylamino)-6-oxo-2-phenyl-1(6H)-pyrimidineacetic acid tert-butyl ester

Guidance literature:

In toluene; acetonitrile; at 80 ℃; for 17h;

DOI:10.3987/COM-12-12432

upstream raw materials:

4-chlorohippuric acid

orthoformic acid triethyl ester

4-chloro-benzoyl chloride

Downstream raw materials:

2-(4-chloro-phenyl)-4-[2-(3-methyl-4-phenyl-3H-thiazol-2-ylidene)-ethylidene]-4H-oxazol-5-one

2-(4-chloro-phenyl)-4-[2-(1-methyl-1H-pyridin-2-ylidene)-ethylidene]-4H-oxazol-5-one

2-(4-chloro-phenyl)-4-[2-(1-methyl-1H-quinolin-4-ylidene)-ethylidene]-4H-oxazol-5-one

2-(4-chloro-phenyl)-4-[2-(1-methyl-1H-quinolin-2-ylidene)-ethylidene]-4H-oxazol-5-one