TRYPTOPHANETHYLESTER

Base Information

• Chemical Name: TRYPTOPHANETHYLESTER
• CAS No.: 6519-66-0
• Molecular Formula: C₁₃H₁₆N₂O₂
• Molecular Weight: 232.282
• Mol file: 6519-66-0.mol

Synonyms:DL-Tryptophan,ethyl ester; Tryptophan, ethyl ester, DL- (8CI)

Chemical Property of TRYPTOPHANETHYLESTER

Chemical Property:

• PSA: 68.11000
• LogP: 2.30110

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRYPTOPHANETHYLESTER

There total 8 articles about TRYPTOPHANETHYLESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + Trp (54-12-6,27732-43-0,80206-30-0,27813-82-7) → DL-tryptophan ethyl ester (6519-66-0,7479-05-2,74126-25-3)

Guidance literature:

ethanol; Trp; With thionyl chloride; Reflux;

With sodium hydrogencarbonate;

DOI:10.1016/j.tetasy.2010.02.011

Reference yield: 91.0%

ethanol (64-17-5) + rac-3-(1H-indol-3-yl)-2-methylpropanoic acid (15142-91-3,69088-73-9) → DL-tryptophan ethyl ester (6519-66-0,7479-05-2,74126-25-3)

Guidance literature:

With thionyl chloride; at 80 ℃; Cooling with ice;

Reference yield:

ethyl 3-(1H-indol-3-yl)-2-nitropropanoate (63971-99-3) → DL-tryptophan ethyl ester (6519-66-0,7479-05-2,74126-25-3)

Guidance literature:

With ethanol; nickel; at 80 - 90 ℃; under 73550.8 Torr; Hydrogenation;

DOI:10.1246/bcsj.32.1165

upstream raw materials:

ethyl α-(hydroxyimino)-β-(N-methylindol-3-yl)propanoate

ethyl 3-(1H-indol-3-yl)-2-nitropropanoate

Trp

indole

Downstream raw materials:

3-(1H-Indol-3-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid ethyl ester

Br(OC)3Re(NH₂CH(CH₂C₆H₅)CONHCH(CH₂C₈H₅NH)CO₂C₂H₅)2

acetyltryptophan ethylester

ethyl 1-(3,4-dimethoxyphenyl)-9H-pyrido[3,4-b]-indole-3-carboxylate