1-(4-fluorophenyl)-3-(morpholin-4-yl)propan-1-one hydrochloride (1:1)

Base Information

Chemical Name:1-(4-fluorophenyl)-3-(morpholin-4-yl)propan-1-one hydrochloride (1:1)
CAS No.:2730-27-0
Molecular Formula:C13H16 F N O2 . Cl H
Molecular Weight:273.735
Hs Code.:

Synonyms:1-Propanone,1-(4-fluorophenyl)-3-(4-morpholinyl)-, hydrochloride (9CI); Propiophenone,4'-fluoro-3-morpholino-, hydrochloride (6CI,8CI)

Suppliers and Price of 1-(4-fluorophenyl)-3-(morpholin-4-yl)propan-1-one hydrochloride (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 1-(4-fluorophenyl)-3-(morpholin-4-yl)propan-1-one hydrochloride (1:1)

Chemical Property:

Vapor Pressure:1.49E-05mmHg at 25°C
Boiling Point:366.2°Cat760mmHg
Flash Point:175.3°C
Density:g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(4-fluorophenyl)-3-(morpholin-4-yl)propan-1-one hydrochloride (1:1)

There total 3 articles about 1-(4-fluorophenyl)-3-(morpholin-4-yl)propan-1-one hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.9%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 10024-89-2
morpholin hydrochloride

: 403-42-9
1-(4-fluorophenyl)ethanone

: 2730-27-0
4-(3-(4-fluorophenyl)-3-oxopropyl)morpholin-4-ium chloride

Guidance literature:: With hydrogenchloride; In ethanol; for 8h; Heating;

Reference yield: 21.2%

: 110-91-8,99108-56-2
morpholine

: 3935-51-1
3-dimethylamino-1-(4-fluorophenyl)propanal hydrochloride

: 2730-27-0
4-(3-(4-fluorophenyl)-3-oxopropyl)morpholin-4-ium chloride

Guidance literature:: morpholine; 3-dimethylamino-1-(4-fluorophenyl)propanal hydrochloride; at 60 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In methanol; diethyl ether; Inert atmosphere;
DOI:10.1016/j.bmcl.2021.127780

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 2730-27-0
4-(3-(4-fluorophenyl)-3-oxopropyl)morpholin-4-ium chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / acetonitrile / 9 h / Reflux; Inert atmosphere

2.1: 0.5 h / 60 °C / Inert atmosphere

2.2: Inert atmosphere

With sulfuric acid; In acetonitrile;
DOI:10.1016/j.bmcl.2021.127780