Ethanol, 2-[2-[2-(4-ethynylphenoxy)ethoxy]ethoxy]-

Base Information

• Chemical Name: Ethanol, 2-[2-[2-(4-ethynylphenoxy)ethoxy]ethoxy]-
• CAS No.: 365134-29-8
• Molecular Formula: C14H18O4
• Molecular Weight: 250.295
• Mol file: 365134-29-8.mol

Synonyms:

Chemical Property of Ethanol, 2-[2-[2-(4-ethynylphenoxy)ethoxy]ethoxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanol, 2-[2-[2-(4-ethynylphenoxy)ethoxy]ethoxy]-

There total 4 articles about Ethanol, 2-[2-[2-(4-ethynylphenoxy)ethoxy]ethoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-{2-[2-(4-trimethylsilylethynylphenoxy)ethoxy]ethoxy}ethanol (365134-19-6) → 2-[2-{2-(4-ethynylphenoxy)ethoxy}ethoxy]ethanol (365134-29-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1002/adsc.201100600

Reference yield:

2-(2-(2-(4-iodophenoxy)ethoxy)ethoxy)ethan-1-ol (187662-48-2) → 2-[2-{2-(4-ethynylphenoxy)ethoxy}ethoxy]ethanol (365134-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;

DOI:10.1002/adsc.201100600

Reference yield:

2-[2-(chloroethoxy)ethoxy]ethanol (5197-62-6) → 2-[2-{2-(4-ethynylphenoxy)ethoxy}ethoxy]ethanol (365134-29-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium iodide; potassium hydroxide / dimethyl sulfoxide; acetone / 24 h / Inert atmosphere; Reflux

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; acetone;

DOI:10.1002/adsc.201100600

upstream raw materials:

2-(2-(2-(4-iodophenoxy)ethoxy)ethoxy)ethan-1-ol

2-{2-[2-(4-trimethylsilylethynylphenoxy)ethoxy]ethoxy}ethanol

2-[2-(chloroethoxy)ethoxy]ethanol

p-Iodophenol

Downstream raw materials:

5-chloro-4,4-difluoro-3-(4-(hydroxy(ethyloxy(ethyloxy(ethyloxy))))phenylethynyl)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indacene

4-{2-[2-(2-acetoxyethoxy)ethoxy]ethoxy}acetophenone

1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one