1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one

Base Information

• Chemical Name: 1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one
• CAS No.: 714273-92-4
• Molecular Formula: C₁₄H₂₀O₅
• Molecular Weight: 268.31
• Mol file: 714273-92-4.mol

Synonyms:1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one

Chemical Property of 1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one

There total 4 articles about 1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-[2-(chloroethoxy)ethoxy]ethanol (5197-62-6) + 4-Hydroxyacetophenone (99-93-4) → 1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one (714273-92-4)

Guidance literature:

With potassium carbonate; potassium iodide; In butan-1-ol; at 110 ℃; for 12h;

DOI:10.1021/jp031188m

Reference yield: 80.5%

8-tosyloxy-3,6-dioxaoctanol (77544-68-4) + 4-Hydroxyacetophenone (99-93-4) → 1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one (714273-92-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1021/jacs.5b10504

Reference yield: 48.0%

2-[2-{2-(4-ethynylphenoxy)ethoxy}ethoxy]ethanol (365134-29-8) → 4-{2-[2-(2-acetoxyethoxy)ethoxy]ethoxy}acetophenone (1567382-76-6) + 1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)ethan-1-one (714273-92-4)

Guidance literature:

With iron(III) sulfate hydrate; acetic acid; at 95 ℃; for 20h; Schlenk technique;

DOI:10.1016/j.tetlet.2014.01.083

upstream raw materials:

2-[2-(chloroethoxy)ethoxy]ethanol

4-Hydroxyacetophenone

2-[2-{2-(4-ethynylphenoxy)ethoxy}ethoxy]ethanol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

4-N,N-dihexadecylamino-4'-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}chalcone

4-N,N-dihexadecylamino-4'-{2-[2-(2-iodoethoxy)ethoxy]ethoxy}chalcone

1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)ethanone