Formamide, N-[2-(4-hydroxyphenyl)ethyl]-N-[[4-methoxy-3,5-bis(phenylmethoxy)phen yl]methyl]-

Base Information

• Chemical Name: Formamide, N-[2-(4-hydroxyphenyl)ethyl]-N-[[4-methoxy-3,5-bis(phenylmethoxy)phen yl]methyl]-
• CAS No.: 374072-03-4
• Molecular Formula: C31H31NO5
• Molecular Weight: 497.591
• Mol file: 374072-03-4.mol

Synonyms:

Chemical Property of Formamide, N-[2-(4-hydroxyphenyl)ethyl]-N-[[4-methoxy-3,5-bis(phenylmethoxy)phen yl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Formamide, N-[2-(4-hydroxyphenyl)ethyl]-N-[[4-methoxy-3,5-bis(phenylmethoxy)phen yl]methyl]-

There total 8 articles about Formamide, N-[2-(4-hydroxyphenyl)ethyl]-N-[[4-methoxy-3,5-bis(phenylmethoxy)phen yl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylamine (412009-82-6) + formic acid ethyl ester (109-94-4) → N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylformamide (374072-03-4)

Guidance literature:

for 6h; Heating;

DOI:10.1248/cpb.54.1662

Reference yield:

4-(2-{[1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-meth-(E)-ylidene]-amino}-ethyl)-phenol → N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylformamide (374072-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.5 g / NaBH₄ / methanol / 1.17 h / 0 - 20 °C

2: 97 percent / 6 h / Heating

With sodium tetrahydroborate; In methanol;

DOI:10.1248/cpb.54.1662

Reference yield:

[3,5-bis(benzyloxy)-4-methoxyphenyl]methanol (27229-56-7) → N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylformamide (374072-03-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / pyridinium chlorochromate / tetrahydrofuran / 3 h / 20 °C

2: methanol / 1.17 h / 70 °C

3: 5.5 g / NaBH₄ / methanol / 1.17 h / 0 - 20 °C

4: 97 percent / 6 h / Heating

With sodium tetrahydroborate; pyridinium chlorochromate; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.54.1662

upstream raw materials:

N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylamine

formic acid ethyl ester

[3,5-bis(benzyloxy)-4-methoxyphenyl]methanol

methyl galloate

Downstream raw materials:

6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one

(4aS,8aS)-rel-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one

galanthamine

Refernces