6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one

Base Information

• Chemical Name: 6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one
• CAS No.: 374072-11-4
• Molecular Formula: C₃₁H₂₉NO₅
• Molecular Weight: 495.575

Synonyms:6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one

Chemical Property of 6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of 6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one

There total 13 articles about 6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylformamide (374072-03-4) → 6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one (374072-11-4)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In 2,2,2-trifluoroethanol; at 20 ℃; for 0.25h;

DOI:10.1002/1521-3773(20010817)40:16<3060::AID-ANIE3060>3.0.CO;2-#

Reference yield: 23.0%

N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylformamide (374072-03-4) → N-(3,5-bis-benzyloxy-4-methoxy-benzyl)-N-[2-(1-hydroxy-4-oxo-cyclohexa-2,5-dienyl)-ethyl]-formamide + 6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one (374072-11-4)

Guidance literature:

With [bis(acetoxy)iodo]benzene; trifluoroacetic acid; at 20 ℃; for 0.75h;

DOI:10.1248/cpb.54.1662

Reference yield: 19.5%

acetic acid (64-19-7,77671-22-8) + N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylformamide (374072-03-4) → acetic acid 1-{2-[(3,5-bis-benzyloxy-4-methoxy-benzyl)-formyl-amino]-ethyl}-4-oxo-cyclohexa-2,5-dienyl ester + 6,8-dibenzyloxy-2-formyl-7-methoxy-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-dien-4'-one (374072-11-4)

Guidance literature:

With [bis(acetoxy)iodo]benzene; at 20 ℃; for 0.666667h;

DOI:10.1248/cpb.54.1662

upstream raw materials:

N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylformamide

acetic acid

isopropyl alcohol

acetonitrile

Downstream raw materials:

(4aS,8aS)-rel-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one

galanthamine

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