2-Chloro-3-methyl-1,3,2-oxazaphospholidine

Base Information

• Chemical Name: 2-Chloro-3-methyl-1,3,2-oxazaphospholidine
• CAS No.: 22082-71-9
• Molecular Formula: C3H7 Cl N O P
• Molecular Weight: 139.521
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40944712
• Mol file: 22082-71-9.mol

Synonyms:2-Chloro-3-methyl-1,3,2-oxazaphospholidine;22082-71-9;SCHEMBL8096108;DTXSID40944712;AKOS006284412;N-methyl-2-chloro-1,3,2-oxaazaphospholane

Chemical Property of 2-Chloro-3-methyl-1,3,2-oxazaphospholidine

Chemical Property:

• Vapor Pressure: 9.43mmHg at 25°C
• Boiling Point: 131.1°Cat760mmHg
• Flash Point: 33.1°C
• PSA: 26.06000
• Density: g/cm³
• LogP: 1.35200
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 138.9953785
• Heavy Atom Count: 7
• Complexity: 72

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-3-METHYL-[1,3,2]OXAZA-PHOSPHOLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCOP1Cl

Technology Process of 2-Chloro-3-methyl-1,3,2-oxazaphospholidine

There total 7 articles about 2-Chloro-3-methyl-1,3,2-oxazaphospholidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-methyl-N-trimethylsilyl-[2-(trimethylsiloxy)ethyl]amine (74982-84-6) → 2-chloro-3-methyl-1,3,2-oxazaphospholidine (22082-71-9)

Guidance literature:

With phosphorus trichloride; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1080/15257771003612839

Reference yield: 57.0%

diethyl phosphorylchloridite (589-57-1) + 2-ethoxy-3-methyl-1,3,2-oxazaphospholidine (7077-42-1) → 2-chloro-3-methyl-1,3,2-oxazaphospholidine (22082-71-9) + triethyl phosphite (122-52-1)

Guidance literature:

at 100 ℃; for 1h;

DOI:10.1007/BF00953486

Reference yield: 51.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) → 2-chloro-3-methyl-1,3,2-oxazaphospholidine (22082-71-9)

Guidance literature:

With phosphorus trichloride; In diethyl ether; at -50 - 20 ℃; for 4h;

DOI:10.1016/j.jorganchem.2006.08.098

upstream raw materials:

(2-hydroxyethyl)(methyl)amine

pyrocatechol phosphorochloridite

2-ethoxy-3-methyl-1,3,2-oxazaphospholidine

N-Ethylmethylamine

Downstream raw materials:

3-Methyl-2-(2,2,2-trifluoro-ethoxy)-[1,3,2]oxazaphospholidine

3,3'-dimethyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

3-methyl-2-phenoxy-1,3,2-oxazaphospholidine

5'-O-DMTr-thymidine 3'-O-oxazaphospholidine