4-Methoxy-2-methyl-1-benzofuran

Base Information

• Chemical Name: 4-Methoxy-2-methyl-1-benzofuran
• CAS No.: 3781-89-3
• Molecular Formula: C10H10O2
• DSSTox Substance ID: DTXSID10517917
• Wikidata: Q82380197
• Mol file: 3781-89-3.mol

Synonyms:4-methoxy-2-methylbenzofuran;3781-89-3;4-Methoxy-2-methyl-1-benzofuran;SCHEMBL9296788;DTXSID10517917

Chemical Property of 4-Methoxy-2-methyl-1-benzofuran

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.068079557
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC2=C(O1)C=CC=C2OC

Technology Process of 4-Methoxy-2-methyl-1-benzofuran

There total 3 articles about 4-Methoxy-2-methyl-1-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-allyloxyanisole (37592-19-1) → 4-methoxy-2-methylbenzofuran (3781-89-3) + 6-methoxy-2-methylbenzofuran (29040-48-0)

Guidance literature:

With sodium carbonate; p-benzoquinone; dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; at 80 ℃; Title compound not separated from byproducts;

DOI:10.1021/ol051264z

Reference yield:

Acetone O-(m-methoxyphenyl)oxime (97946-21-9) → 4-methoxy-2-methylbenzofuran (3781-89-3) + 6-methoxy-2-methylbenzofuran (29040-48-0)

Guidance literature:

With sulfuric acid; In ethanol; for 3h; Yield given. Yields of byproduct given; Heating;

DOI:10.1055/s-1987-27888

Reference yield:

m-methoxyphenyl 2-propynyl ether (41580-72-7) → 3-chromene (18385-89-2) + 4-methoxy-2-methylbenzofuran (3781-89-3) + 6-methoxy-2-methylbenzofuran (29040-48-0) + 5-methoxybenzopyran (41580-69-2)

Guidance literature:

With cesium fluoride; N,N-diethylaniline; for 8h; Heating;

DOI:10.3987/COM-94-S(B)46

upstream raw materials:

Acetone O-(m-methoxyphenyl)oxime

m-methoxyphenyl 2-propynyl ether

3-allyloxyanisole