29040-48-0

Usage

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 1867, 1989 DOI: 10.1016/S0040-4039(00)99601-1

Upstream product

• 122-84-9 4-methoxybenzyl methyl ketone 
• 97946-21-9 Acetone O-(m-methoxyphenyl)oxime 
• 41580-72-7 m-methoxyphenyl 2-propynyl ether 
• 678554-43-3 C₁₅H₁₆N₂O₄S 
• 150-19-6 O-methylresorcine 
• 37592-19-1 3-allyloxyanisole 
• 41046-70-2 2-iodo-5-methoxyphenol 
• 74-99-7 prop-1-yne 

Downstream Products

• 54584-24-6 6-hydroxy-2-methylbenzofuran 
• 638217-07-9 6-methoxy-2-methylbenzofuran-3-carboxylic acid methylamide 

Relevant academic research and scientific papers

A ONE STEP SYNTHESIS OF 2-SUBSTITUTED BENZOFURANS FROM 2-ARYL-1-SUBSTITUTED ETHANE-1-ONES BY PHOTOINDUCED SET REACTIONS

An efficient one step synthesis of 2-substituted Benzofurans from the enolate of 2-Aryl-1-substituted ethane-1-ones by photoinduced SET has been reported.

Aromatic Nucleophilic Substitution on Cr(CO)3-Complexed Halogenoarenes: A New Synthesis of O-Aryloximes and Their Cyclization to Benzofurans

O-Aryloximes are synthesized by reaction of acetone oxime with Cr(CO)3-complexed halogenoarenes and then cyclized to give benzofurans.

Direct Synthesis of 2-Methylbenzofurans from Calcium Carbide and Salicylaldehyde p -Tosylhydrazones

A new methodology for the construction of methyl-substituted benzofuran rings from the reactions of calcium carbide with salicylaldehyde p-tosylhydrazones/2-hydroxyacetophenone p-tosylhydrazones is described. Various 2-methylbenzofurans and 2,3-dimethylbenzofurans could be obtained in satisfactory yield by using a cuprous chloride catalyst. The advantages of this protocol include the use of a readily available and easy-to-handle acetylene source and simple workup procedure.

COMPOUNDS AND METHODS FOR MODULATING FXR

Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Facile construction of the benzofuran and chromene ring systems via Pd II-catalyzed oxidative cyclization

(Chemical Equation Presented) We herein report the development of one-pot procedures for the conversion of allyl aryl ethers to 2-methylbenzofurans (via sequential Claisen rearrangement and oxidative cyclization) and for the conversion of aryl homoallyl e

NOVEL QUINOLINE DERIVATIVES

The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R3-8, X3, X5, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).

Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use

The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

BENZOFUSED HETEROARYL AMIDE DERIVATIVES OF THIENOPYRIDINES USEFUL AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME, AND METHODS FOR THEIR USE

The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Cesium Fluoride-Mediated Claisen Rearrangements of Phenyl Propargyl Ethers: Effect of a Substituent on the Phenyl Ring on the Rearrangement

Methoxy or methoxycarbonyl-substituted phenyl propargyl ethers were subjected to Claisen rearrangement either in the absence or in the presence of CsF.Substituent effect on the cyclization is discussed.

Nucleophilic Aromatic Substitution on Tricarbonylchromium-complexed Haloarenes: Synthesis of O-Aryloximes and Their Cyclization to Benzofurans

A series of O-aryloximes have been prepared from tricarbonylchromium-complexed haloarenes in mild conditions.Title compounds are starting materials for benzofuran synthesis.