4-(4-Methoxyanilino)-4-oxobut-2-enoic acid

Base Information

Chemical Name:4-(4-Methoxyanilino)-4-oxobut-2-enoic acid
CAS No.:37904-20-4
Molecular Formula:C11H11NO4
Molecular Weight:221.213
Hs Code.:
NSC Number:61570
DSSTox Substance ID:DTXSID001214072
Nikkaji Number:J2.128.427K,J2.207.615I
ChEMBL ID:CHEMBL1085181

Synonyms:37902-60-6;4-(4-methoxyanilino)-4-oxobut-2-enoic acid;(E)-4-(4-methoxyanilino)-4-oxo-2-butenoic acid;(E)-4-(4-methoxyanilino)-4-oxobut-2-enoic acid;(2E)-4-[(4-methoxyphenyl)amino]-4-oxobut-2-enoic acid;37904-20-4;4-((4-Methoxyphenyl)amino)-4-oxobut-2-enoic acid;(2E)-3-[(4-methoxyphenyl)carbamoyl]prop-2-enoic acid;(2E)-4-(4-methoxyanilino)-4-oxo-2-butenoic acid;NSC61570;SCHEMBL890966;CHEMBL1085181;SCHEMBL13174794;DTXSID001214072;MFCD00663030;NSC-61570;AKOS000496639;4-Oxo-4-(4-methoxyanilino)crotonic acid;LS-07289;4-(4-methoxyanilino)-4-oxo-2-butenoic acid;4-(4-Methoxyphenylamino)-4-oxo-2-butenoic acid;A823928;AF-601/00273053;SR-01000511055;SR-01000511055-1;(E)-4-(4-methoxyphenylamino)-4-oxobut-2-enoic acid;Z56174311;(2E)-4-[(4-Methoxyphenyl)amino]-4-oxo-2-butenoic acid;(E)-4-[(4-methoxyphenyl)amino]-4-oxidanylidene-but-2-enoic acid

Suppliers and Price of 4-(4-Methoxyanilino)-4-oxobut-2-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-(4-Methoxyanilino)-4-oxobut-2-enoic acid

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:221.06880783
Heavy Atom Count:16
Complexity:280

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)NC(=O)C=CC(=O)O
Isomeric SMILES:COC1=CC=C(C=C1)NC(=O)/C=C/C(=O)O

Technology Process of 4-(4-Methoxyanilino)-4-oxobut-2-enoic acid

There total 8 articles about 4-(4-Methoxyanilino)-4-oxobut-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2459-05-4
(E)-4-ethoxy-4-oxobut-2-enoic acid

: 104-94-9
4-methoxy-aniline

: 37904-20-4
(E)–4-((4-methoxyphenyl)amino)-4-oxobut-2-enoic acid

Guidance literature:: (E)-4-ethoxy-4-oxobut-2-enoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; at 20 ℃; for 4h; Inert atmosphere;

4-methoxy-aniline; With caesium carbonate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With potassium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/ejoc.200800781

Reference yield: 84.0%

: 108-31-6
maleic anhydride

: 104-94-9
4-methoxy-aniline

: 24870-10-8,37904-20-4,37902-60-6
maleic acid mono(4-methoxyphenyl)amide

Guidance literature:: With sodium dodecyl-sulfate; In water;
DOI:10.1002/ejoc.200300620

Reference yield:

: 104-94-9
4-methoxy-aniline

: 26367-48-6
fumaric acid ethyl ester mono chloride

: 37904-20-4
(E)–4-((4-methoxyphenyl)amino)-4-oxobut-2-enoic acid

Guidance literature:: 4-methoxy-aniline; fumaric acid ethyl ester mono chloride; With caesium carbonate; In tetrahydrofuran; at 20 ℃; for 12h;

With potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.tetlet.2004.11.115