6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, ethyl ester, (3S,5S,6E)-

Base Information

Chemical Name:6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, ethyl ester, (3S,5S,6E)-
CAS No.:380848-30-6
Molecular Formula:C₂₇H₂₈FNO₄
Molecular Weight:449.522
Hs Code.:
Mol file:380848-30-6.mol

Synonyms:(3R,5S)DOLE;ethyl (3S,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate;

Suppliers and Price of 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, ethyl ester, (3S,5S,6E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, ethyl ester, (3S,5S,6E)-

Chemical Property:

PSA：79.65000
LogP:4.99660

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, ethyl ester, (3S,5S,6E)-

There total 10 articles about 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, ethyl ester, (3S,5S,6E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 0.3%

: 477950-34-8,172336-32-2,172336-33-3
ethyl (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enoate

: 167073-18-9,172336-32-2,172336-33-3
(E)7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-(3S,5R)-dihydroxyhept-6-enic acid ethyl ester

: 380848-32-8,172336-32-2,172336-33-3
(E)7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-(3R,5R)-dihydroxyhept-6-enic acid ethyl ester

: 380848-30-6,172336-32-2,172336-33-3
(E)7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-(3S,5S)-dihydroxyhept-6-enic acid ethyl ester

: 167073-19-0,172336-32-2,172336-33-3
(E)-(3R,5S)-7-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester

Guidance literature:: With 1473; Purification / work up;

Reference yield:

: 121660-11-5
2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline

: 380848-30-6,172336-32-2,172336-33-3
(E)7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-(3S,5S)-dihydroxyhept-6-enic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: DMSO; P₂O₅; Et₃N

2: NaOH; (n-octyl)3MeNCl / toluene; H₂O

3: DIBAH

4: LDA; MgBr₂

6: LDA

7: Me₄NHB(OAc)3 / acetic acid

With sodium hydroxide; phosphorus pentoxide; Aliquat 336; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; magnesium bromide; tetramethylammonium triacetoxyborohydride; lithium diisopropyl amide; In water; acetic acid; toluene; 1: Oxidation / 2: Condensation / 3: Reduction / 4: Addition / 5: Methylation / 6: Claisen condensation / 7: Reduction;
DOI:10.1016/S0960-894X(99)00519-3

Reference yield:

: 121660-37-5
2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline

: 380848-30-6,172336-32-2,172336-33-3
(E)7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-(3S,5S)-dihydroxyhept-6-enic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH; (n-octyl)3MeNCl / toluene; H₂O

2: DIBAH

3: LDA; MgBr₂

5: LDA

6: Me₄NHB(OAc)3 / acetic acid

With sodium hydroxide; Aliquat 336; diisobutylaluminium hydride; magnesium bromide; tetramethylammonium triacetoxyborohydride; lithium diisopropyl amide; In water; acetic acid; toluene; 1: Condensation / 2: Reduction / 3: Addition / 4: Methylation / 5: Claisen condensation / 6: Reduction;
DOI:10.1016/S0960-894X(99)00519-3