Oxirane, 2-(3-methylphenyl)-3-phenyl-, (2R,3R)-rel-

Base Information

• Chemical Name: Oxirane, 2-(3-methylphenyl)-3-phenyl-, (2R,3R)-rel-
• CAS No.: 38503-20-7
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.276
• Mol file: 38503-20-7.mol

Synonyms:

Chemical Property of Oxirane, 2-(3-methylphenyl)-3-phenyl-, (2R,3R)-rel-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Oxirane, 2-(3-methylphenyl)-3-phenyl-, (2R,3R)-rel-

There total 7 articles about Oxirane, 2-(3-methylphenyl)-3-phenyl-, (2R,3R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl bromide (100-39-0) + m-tolyl aldehyde (620-23-5) → trans-3-phenyl-2-(m-tolyl)oxirane (38503-20-7,52881-63-7)

Guidance literature:

With caesium carbonate; In thiophene; acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01838

Reference yield: 52.0%

1-benzyl-3-methylbenzotriazolium iodide (1334478-48-6) + m-tolyl aldehyde (620-23-5) → C15H15N3O (1356453-08-1) + trans-3-phenyl-2-(m-tolyl)oxirane (38503-20-7,52881-63-7)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; tert-butyl alcohol; at 20 ℃; optical yield given as %de; diastereoselective reaction;

DOI:10.1055/s-0031-1289555

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + trans-3-phenyl-2-(m-tolyl)oxirane (38503-20-7,52881-63-7) → (2R,3R)-2-phenyl-3-(m-tolyl)oxirane (38503-20-7,52881-63-7) + (2S,3S)-2-phenyl-3-(m-tolyl)oxirane + C16H14O3 + C16H14O3

Guidance literature:

With C₆₂H₃₃F₁₂N₇O₈; tetra-(n-butyl)ammonium iodide; at 50 ℃; for 120h; under 760.051 Torr; enantioselective reaction;

DOI:10.1021/acs.orglett.7b01838

upstream raw materials:

(E)-3-methylstilbene

α,α-dichloro-m-xylene

benzaldehyde

benzylidene dichloride

Downstream raw materials:

(2R,3R)-2-phenyl-3-(m-tolyl)oxirane