4-(Dimethylphenylsilyl)-3,5-dimethylisoxazole

Base Information

Chemical Name:4-(Dimethylphenylsilyl)-3,5-dimethylisoxazole
CAS No.:387353-84-6
Molecular Formula:C13H17NOSi
Molecular Weight:231.37
Hs Code.:
DSSTox Substance ID:DTXSID701254772
Nikkaji Number:J1.645.596B

Synonyms:DTXSID701254772;387353-84-6;4-(Dimethylphenylsilyl)-3,5-dimethylisoxazole

Suppliers and Price of 4-(Dimethylphenylsilyl)-3,5-dimethylisoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(Dimethylphenylsilyl)-3,5-dimethylisoxazole

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:231.107940700
Heavy Atom Count:16
Complexity:238

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NO1)C)[Si](C)(C)C2=CC=CC=C2

Technology Process of 4-(Dimethylphenylsilyl)-3,5-dimethylisoxazole

There total 3 articles about 4-(Dimethylphenylsilyl)-3,5-dimethylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 10557-85-4
4-iodo-3,5-dimethylisoxazole

: 387353-84-6
3,5-dimethyl-4-dimethylphenylsilylisoxazole

Guidance literature:: In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1055/s-2001-17699

Reference yield: 70.0%

: 10557-85-4
4-iodo-3,5-dimethylisoxazole

: 768-33-2
phenyldimethylsilyl chloride

: 387353-84-6
3,5-dimethyl-4-dimethylphenylsilylisoxazole

Guidance literature:: 4-iodo-3,5-dimethylisoxazole; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -50 ℃; for 5h;

phenyldimethylsilyl chloride; In tetrahydrofuran; at -50 - 0 ℃;
DOI:10.1055/s-2001-17699

Reference yield: 51.0%

: 10558-25-5
4-bromo-3,5-dimethyl-1,2-oxazole

: 185990-03-8
dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

: 832114-00-8
3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole

: 387353-84-6
3,5-dimethyl-4-dimethylphenylsilylisoxazole

Guidance literature:: dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane; With potassium methanolate; In 1,2-dimethoxyethane; at 30 ℃; for 0.166667h;

4-bromo-3,5-dimethyl-1,2-oxazole; In 1,2-dimethoxyethane; at 30 ℃; for 1h; Overall yield = 57 %;
DOI:10.1039/c5sc00384a