Ethyl 2-methoxyacrylate

Base Information

• Chemical Name: Ethyl 2-methoxyacrylate
• CAS No.: 36997-05-4
• Molecular Formula: C6H10 O3
• Molecular Weight: 130.144
• Hs Code.: 2918990090
• European Community (EC) Number: 253-304-2
• DSSTox Substance ID: DTXSID60885658
• Nikkaji Number: J260.716F
• Wikidata: Q82864315
• Mol file: 36997-05-4.mol

Synonyms:Ethyl 2-methoxyacrylate;36997-05-4;Ethyl 2-methoxy-2-propenoate;2-Propenoic acid, 2-methoxy-, ethyl ester;EINECS 253-304-2;2-Methoxyacrylic acid ethyl ester;methoxy ethyl acrylate;SCHEMBL197959;DTXSID60885658

Chemical Property of Ethyl 2-methoxyacrylate

Chemical Property:

• Vapor Pressure: 4.02mmHg at 25°C
• Boiling Point: 149.5°Cat760mmHg
• Flash Point: 50.8°C
• PSA: 35.53000
• Density: 0.983g/cm³
• LogP: 0.70960
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 130.062994177
• Heavy Atom Count: 9
• Complexity: 118

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(=C)OC

Technology Process of Ethyl 2-methoxyacrylate

There total 2 articles about Ethyl 2-methoxyacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-oxo-propionic acid ethyl ester (617-35-6) + trimethyl orthoformate (149-73-5) → 2-methoxyacrylic acid ethyl ester (36997-05-4)

Guidance literature:

2-oxo-propionic acid ethyl ester; trimethyl orthoformate; With sulfuric acid; at 20 ℃; for 6h;

With phosphorus pentoxide; In N,N-dimethyl-formamide; at 100 ℃; for 6h; Further stages.;

DOI:10.1016/j.tet.2004.09.001

Reference yield:

3-Chlor-2-methoxypropionsaeureethylester (36997-04-3) → 2-methoxyacrylic acid ethyl ester (36997-05-4)

Guidance literature:

With triethylamine; In benzene;

Reference yield: 86.0%

2-methoxyacrylic acid ethyl ester (36997-05-4) + Cyclohexyl iodide (626-62-0) → ethyl 3-cyclohexyl-2-methoxypropanoate

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) bromide dimethoxyethane; 1,1,1,3',3',3'-hexafluoro-propanol; zinc; In tetrahydrofuran; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tet.2019.05.002

upstream raw materials:

3-Chlor-2-methoxypropionsaeureethylester

2-oxo-propionic acid ethyl ester

trimethyl orthoformate

Downstream raw materials:

(+)-1-Methoxy-2.2-diphenylcyclopropancarbonsaeure

1-Methoxy-2.2-diphenylcyclopropancarbonsaeureaethylester

(-)-(S)-1-Methoxy-2,2-diphenyl-cyclopropancarbonsaeure

methyl 6-bromo-2-phenylquinoline-4-carboxylate