Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[2'-[[(1,1-dimethylethyl)amino ]sulfonyl][1,1'-biphenyl]-4-yl]amino]-5-oxo-, cyclohexyl ester, (4S)-

Base Information

Chemical Name:Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[2'-[[(1,1-dimethylethyl)amino ]sulfonyl][1,1'-biphenyl]-4-yl]amino]-5-oxo-, cyclohexyl ester, (4S)-
CAS No.:398476-84-1
Molecular Formula:C₃₂H₄₅N₃O₇S
Molecular Weight:615.791
Hs Code.:

Pentanoic acid,
4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[2'-[[(1,1-dimethylethyl)amino
]sulfonyl][1,1'-biphenyl]-4-yl]amino]-5-oxo-, cyclohexyl ester, (4S)-

Synonyms:

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Chemical Property of Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[2'-[[(1,1-dimethylethyl)amino ]sulfonyl][1,1'-biphenyl]-4-yl]amino]-5-oxo-, cyclohexyl ester, (4S)-

Chemical Property:

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Technology Process of Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[2'-[[(1,1-dimethylethyl)amino ]sulfonyl][1,1'-biphenyl]-4-yl]amino]-5-oxo-, cyclohexyl ester, (4S)-

There total 4 articles about Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[2'-[[(1,1-dimethylethyl)amino ]sulfonyl][1,1'-biphenyl]-4-yl]amino]-5-oxo-, cyclohexyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73821-97-3,133464-27-4
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 398476-84-1
4-tert-butoxycarbonylamino-4-(2'-tert-butylsulfamoyl-biphenyl-4-ylcarbamoyl)-butyric acid cyclohexyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0960-894X(01)00585-6

Reference yield:

: 2512-24-5
N-tert-butylbenzenesulfonamide

: 398476-84-1
4-tert-butoxycarbonylamino-4-(2'-tert-butylsulfamoyl-biphenyl-4-ylcarbamoyl)-butyric acid cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi; B(i-PrO)3 / tetrahydrofuran

1.2: 1N aq. HCl / tetrahydrofuran

2.1: Pd(Ph₃P)4; Bu₄NBr; NaOH / toluene

3.1: BOP; DIEA / dimethylformamide / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; tetrabutylammomium bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(01)00585-6

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 398476-84-1
4-tert-butoxycarbonylamino-4-(2'-tert-butylsulfamoyl-biphenyl-4-ylcarbamoyl)-butyric acid cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: TEA / CH₂Cl₂

2.1: BuLi; B(i-PrO)3 / tetrahydrofuran

2.2: 1N aq. HCl / tetrahydrofuran

3.1: Pd(Ph₃P)4; Bu₄NBr; NaOH / toluene

4.1: BOP; DIEA / dimethylformamide / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; TEA; tetrabutylammomium bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(01)00585-6