2(1H)-Isoquinolinecarboxylic acid, 3-[[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]amino]carb onyl]-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester, (3S)-

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 3-[[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]amino]carb onyl]-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester, (3S)-
CAS No.:398476-90-9
Molecular Formula:C₃₁H₃₇N₃O₆S
Molecular Weight:579.717
Hs Code.:

2(1H)-Isoquinolinecarboxylic acid,
3-[[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]amino]carb
onyl]-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester, (3S)-

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]amino]carb onyl]-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester, (3S)-

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Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]amino]carb onyl]-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester, (3S)-

There total 4 articles about 2(1H)-Isoquinolinecarboxylic acid, 3-[[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]amino]carb onyl]-3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 6-hydroxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester

: 398476-90-9
3-(2'-tert-butylsulfamoyl-biphenyl-4-ylcarbamoyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0960-894X(01)00585-6

Reference yield:

: 2512-24-5
N-tert-butylbenzenesulfonamide

: 398476-90-9
3-(2'-tert-butylsulfamoyl-biphenyl-4-ylcarbamoyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi; B(i-PrO)3 / tetrahydrofuran

1.2: 1N aq. HCl / tetrahydrofuran

2.1: Pd(Ph₃P)4; Bu₄NBr; NaOH / toluene

3.1: BOP; DIEA / dimethylformamide / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; tetrabutylammomium bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(01)00585-6

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 398476-90-9
3-(2'-tert-butylsulfamoyl-biphenyl-4-ylcarbamoyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: TEA / CH₂Cl₂

2.1: BuLi; B(i-PrO)3 / tetrahydrofuran

2.2: 1N aq. HCl / tetrahydrofuran

3.1: Pd(Ph₃P)4; Bu₄NBr; NaOH / toluene

4.1: BOP; DIEA / dimethylformamide / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; TEA; tetrabutylammomium bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(01)00585-6