2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl-

Base Information

• Chemical Name: 2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl-
• CAS No.: 39876-23-8
• Molecular Formula: C16H12O4
• Molecular Weight: 268.26400
• Mol file: 39876-23-8.mol

Synonyms:4-Hydroxy-6-methoxy-3-phenyl-cumarin;4-hydroxy-6-methoxy-3-phenylcoumarin;2H-1-Benzopyran-2-one,4-hydroxy-6-methoxy-3-phenyl;2-hydroxy-6-methoxy-3-phenylchromen-4-one;4-hydroxy-6-methoxy-3-phenyl-2H-chromen-2-one;6-methoxy-3-phenyl-4-hydroxy-coumarin;4-hydroxy-6-methoxy-3-phenyl-1-benzopyran-2-one;

Chemical Property of 2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl-

Chemical Property:

• PSA: 59.67000
• LogP: 3.17420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl-

There total 7 articles about 2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 2,3-dihydroxy-3-(2-hydroxy-5-methoxyphenyl)-2-phenylpropanoate → 4-hydroxy-6-methoxy-3-phenyl-1-benzopyran-2-one (39876-23-8)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 5h; Heating;

DOI:10.1055/s-1993-25808

Reference yield: 91.0%

dimethyl 2-phenylmalonate (37434-59-6) + 4-methoxy-phenol (150-76-5) → 4-hydroxy-6-methoxy-3-phenyl-1-benzopyran-2-one (39876-23-8)

Guidance literature:

dimethyl 2-phenylmalonate; 4-methoxy-phenol; In diphenylether; at 200 - 250 ℃; for 3h;

In diphenylether; for 2h; Heating;

DOI:10.3390/molecules17089245

Reference yield: 53.0%

4-hydroxy-6-methoxycoumarin (13252-84-1) + phenyllead(IV) triacetate (3076-54-8) → 4-hydroxy-6-methoxy-3-phenyl-1-benzopyran-2-one (39876-23-8)

Guidance literature:

for 16h;

upstream raw materials:

4-methoxy-phenol

diethyl 2-phenylmalonate

4-hydroxy-6-methoxycoumarin

phenyllead(IV) triacetate

Downstream raw materials:

6-methoxy-4-(2-morpholin-4-yl-ethoxy)-3-phenyl-chromen-2-one

4-acetoxy-6-methoxy-3-phenyl-coumarin