N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide

Base Information

Chemical Name:N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide
CAS No.:68256-41-7
Molecular Formula:C16H24ClN3O4S
Molecular Weight:389.8975
Hs Code.:
DSSTox Substance ID:DTXSID80987784
ChEMBL ID:CHEMBL14845

Synonyms:BRN 0498779;4-Chloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-((methylsulfonyl)amino)benzamide;Benzamide, 4-chloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-((methylsulfonyl)amino)-;N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide;68256-41-7;C16H24ClN3O4S;CHEMBL14845;SCHEMBL11084314;DTXSID80987784;ZUNMZCCDRLBDHW-UHFFFAOYSA-N;C16-H24-Cl-N3-O4-S;LS-26093;N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide;4-Chloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-[(methanesulfonyl)amino]-2-methoxybenzene-1-carboximidic acid

Suppliers and Price of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.301g/cm³
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:389.1176051
Heavy Atom Count:25
Complexity:554

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)Cl)NS(=O)(=O)C

Technology Process of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide

There total 6 articles about N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 68255-79-8
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-aminobenzamide

: 124-63-0
methanesulfonyl chloride

: 68256-41-7
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-methanesulfonamidobenzamide

Guidance literature:: With pyridine; for 0.5h; Ambient temperature;
DOI:10.1021/jm00375a009

Reference yield:

: 26116-12-1
1-ethyl-2-pyrrolidinemethanamine

: 68256-41-7
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-methanesulfonamidobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.25 h / Ambient temperature

2: 81 percent / Sn, HCl aq. / 4 h / 50 °C

3: 25 percent / pyridine / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; tin; triethylamine; In dichloromethane;
DOI:10.1021/jm00375a009

Reference yield:

: 68255-77-6
2-methoxy-4-chloro-5-nitrobenzoic acid

: 68256-41-7
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-methanesulfonamidobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 0.5 h / Heating

2: Et₃N / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 81 percent / Sn, HCl aq. / 4 h / 50 °C

4: 25 percent / pyridine / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; tin; thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm00375a009