1-{(E)-[(E)-[2-(4-chlorophenyl)hydrazinylidene](phenyl)methyl]diazenyl}-2-(4-phenylpiperazin-1-yl)ethanone

Base Information

• Chemical Name: 1-{(E)-[(E)-[2-(4-chlorophenyl)hydrazinylidene](phenyl)methyl]diazenyl}-2-(4-phenylpiperazin-1-yl)ethanone
• CAS No.: 127718-33-6
• Molecular Formula: C₂₅H₂₅ClN₆O
• Molecular Weight: 460.966
• Mol file: 127718-33-6.mol

Synonyms:1-Piperazineaceticacid, 4-phenyl-, [[(4-chlorophenyl)azo]phenylmethylene]hydrazide (9CI)

Chemical Property of 1-{(E)-[(E)-[2-(4-chlorophenyl)hydrazinylidene](phenyl)methyl]diazenyl}-2-(4-phenylpiperazin-1-yl)ethanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 601.2°Cat760mmHg
• Flash Point: 317.4°C
• Density: 1.25g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-{(E)-[(E)-[2-(4-chlorophenyl)hydrazinylidene](phenyl)methyl]diazenyl}-2-(4-phenylpiperazin-1-yl)ethanone

There total 3 articles about 1-{(E)-[(E)-[2-(4-chlorophenyl)hydrazinylidene](phenyl)methyl]diazenyl}-2-(4-phenylpiperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) → (4-Phenyl-piperazin-1-yl)-acetic acid [1-(4-chloro-phenylazo)-1-phenyl-meth-(E)-ylidene]-hydrazide (127718-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetic acid / ethanol / 5 h / Heating

2: 1.) sodium nitrite, HCl / 1.) gl. acetic acid, 0-5 deg C, 2.) pyridine, RT, overnight

With hydrogenchloride; acetic acid; sodium nitrite; In ethanol;

Reference yield:

4-phenyl-1-piperazineacetic acid hydrazide (1689-05-0) → (4-Phenyl-piperazin-1-yl)-acetic acid [1-(4-chloro-phenylazo)-1-phenyl-meth-(E)-ylidene]-hydrazide (127718-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetic acid / ethanol / 5 h / Heating

2: 1.) sodium nitrite, HCl / 1.) gl. acetic acid, 0-5 deg C, 2.) pyridine, RT, overnight

With hydrogenchloride; acetic acid; sodium nitrite; In ethanol;

Reference yield:

4-chloro-aniline (106-47-8) + 4-phenyl-1-piperazineacetic acid benzylidenehydrazide (67041-03-6) → (4-Phenyl-piperazin-1-yl)-acetic acid [1-(4-chloro-phenylazo)-1-phenyl-meth-(E)-ylidene]-hydrazide (127718-33-6)

Guidance literature:

With hydrogenchloride; sodium nitrite; Yield given. Multistep reaction; 1.) gl. acetic acid, 0-5 deg C, 2.) pyridine, RT, overnight;

upstream raw materials:

4-chloro-aniline

4-phenyl-1-piperazineacetic acid benzylidenehydrazide

benzaldehyde

4-phenyl-1-piperazineacetic acid hydrazide