4-Phenyl-1-piperazineacetic acid (phenylmethylene)hydrazide

Base Information

• Chemical Name: 4-Phenyl-1-piperazineacetic acid (phenylmethylene)hydrazide
• CAS No.: 67041-03-6
• Molecular Formula: C19H22N4O
• Molecular Weight: 322.4042

Synonyms:BRN 0838099;4-Phenyl-1-piperazineacetic acid (phenylmethylene)hydrazide;1-Piperazineacetic acid, 4-phenyl-, (phenylmethylene)hydrazide;67041-03-6;LS-110134

Chemical Property of 4-Phenyl-1-piperazineacetic acid (phenylmethylene)hydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.14g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 322.17936134
• Heavy Atom Count: 24
• Complexity: 406

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CC(=O)NN=CC2=CC=CC=C2)C3=CC=CC=C3
• Isomeric SMILES: C1CN(CCN1CC(=O)N/N=C/C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 4-Phenyl-1-piperazineacetic acid (phenylmethylene)hydrazide

There total 4 articles about 4-Phenyl-1-piperazineacetic acid (phenylmethylene)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzaldehyde (100-52-7) + 4-phenyl-1-piperazineacetic acid hydrazide (1689-05-0) → 4-phenyl-1-piperazineacetic acid benzylidenehydrazide (67041-03-6)

Guidance literature:

With acetic acid; In ethanol; for 5h; Heating;

Reference yield:

4-phenyl-1-piperazine (92-54-6) → 4-phenyl-1-piperazineacetic acid benzylidenehydrazide (67041-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: hydrazine hydrate / ethanol

3: acetic acid

With potassium carbonate; hydrazine hydrate; In ethanol; acetic acid; acetone;

DOI:10.1007/s10495-018-1439-x

Reference yield:

ethyl 2-(4-phenyl-piperarazin-1-yl)acetate (56968-26-4) → 4-phenyl-1-piperazineacetic acid benzylidenehydrazide (67041-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol

2: acetic acid

With hydrazine hydrate; In ethanol; acetic acid;

DOI:10.1007/s10495-018-1439-x

upstream raw materials:

benzaldehyde

4-phenyl-1-piperazineacetic acid hydrazide

4-phenyl-1-piperazine

ethyl 2-(4-phenyl-piperarazin-1-yl)acetate

Downstream raw materials:

(4-Phenyl-piperazin-1-yl)-acetic acid [1-(4-chloro-phenylazo)-1-phenyl-meth-(E)-ylidene]-hydrazide

(4-Phenyl-piperazin-1-yl)-acetic acid [1-(4-methoxy-phenylazo)-1-phenyl-meth-(E)-ylidene]-hydrazide

(4-Phenyl-piperazin-1-yl)-acetic acid [1-(2-chloro-phenylazo)-1-phenyl-meth-(E)-ylidene]-hydrazide

1-Phenyl-4-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperazine

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