2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE

Base Information

• Chemical Name: 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
• CAS No.: 5028-17-1
• Molecular Formula: C₁₀H₁₆N₄
• Molecular Weight: 192.264
• Hs Code.: 2933990090
• Mol file: 5028-17-1.mol

Synonyms:Piperazine,1-(3-amino-2-pyridyl)-4-methyl- (7CI,8CI)

Chemical Property of 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE

Chemical Property:

• Vapor Pressure: 2.05E-05mmHg at 25°C
• Melting Point: 112-114°C
• Boiling Point: 361.6°Cat760mmHg
• PKA: 9.35±0.29(Predicted)
• Flash Point: 172.5°C
• PSA: 45.39000
• Density: 1.142g/cm³
• LogP: 0.99970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methylpiperazin-1-yl)pyridin-3-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE

There total 7 articles about 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-methyl-4-(3-nitro-pyridin-2-yl)-piperazine (5028-15-9) → 2-(4-methylpiperazin-1-yl)pyridin-3-amine (5028-17-1)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h;

Reference yield: 72.0%

1-methyl-piperazine (109-01-3) + 2-chloro-3-aminopyridine (6298-19-7) → 2-(4-methylpiperazin-1-yl)pyridin-3-amine (5028-17-1)

Guidance literature:

for 24h; Heating;

DOI:10.1080/00304949809355330

Reference yield: 70.0%

6-bromo-2-(4-methyl-piperazin-1-yl)-pyridin-3-ylamine (220499-48-9) → 2-(4-methylpiperazin-1-yl)pyridin-3-amine (5028-17-1)

Guidance literature:

With hydrazine hydrate; calcium carbonate; palladium on activated charcoal; In ethanol; for 2h; Heating;

DOI:10.1080/00304949809355330

upstream raw materials:

1-methyl-piperazine

2-chloro-3-aminopyridine

6-bromo-2-(4-methyl-piperazin-1-yl)-pyridin-3-ylamine

2,6-dibromo-3-aminopyridine

Refernces

• 1、 -. "INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS". Paragraph 00304. . Retrieved 2013/03/28.
• 2、 Dunn. "The synthesis of 3-amino-2-dialkylaminopyridines". . p. 709 - 713. Retrieved 2007/10/03.