Tert-Butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

• Chemical Name: Tert-Butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate
• CAS No.: 400801-82-3
• Molecular Formula: C17H21N3O2
• Molecular Weight: 299.36800
• Hs Code.: 2933990090
• Mol file: 400801-82-3.mol

Synonyms:TERT-BUTYL 4-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-5,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE;

Chemical Property of Tert-Butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

• PSA: 58.22000
• LogP: 3.52500

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tert-Butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 2 articles about Tert-Butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

7-Azaindole (271-63-6) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate (400801-82-3)

Guidance literature:

With sodium methylate; In methanol; for 2.5h; Heating / reflux;

Reference yield:

→ tert-butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate (400801-82-3)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

tert-butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate (400801-82-3) → tert-butyl 4-(6-((3,4-difluorophenyl)amino)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate (1342812-95-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 48 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

3.1: Benzoyl bromide; 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 12 h / 20 °C

3.2: 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4.2: 19 h / 20 °C

5.1: palladium diacetate; potassium carbonate; XPhos / tert-butyl alcohol / 3 h / Inert atmosphere

With Benzoyl bromide; palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium hydride; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; XPhos; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 5.1: |Buchwald-Hartwig Coupling;

DOI:10.1016/j.bmcl.2017.02.001

upstream raw materials:

7-Azaindole

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

tert-butyl 4-(6-((3,4-difluorophenyl)amino)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate

N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 400801-82-3 Tert-Butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send