N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

Base Information

Chemical Name:N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine
CAS No.:1342949-34-1
Molecular Formula:C₁₈H₁₈F₂N₄
Molecular Weight:328.365
Hs Code.:

Synonyms:N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

Suppliers and Price of N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

There total 9 articles about N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: tert-butyl 4-(6-((3,4-difluorophenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate

: 1342949-34-1
N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2017.02.001

Reference yield:

: 400801-82-3
tert-butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1342949-34-1
N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 48 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

3.1: Benzoyl bromide; 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 12 h / 20 °C

3.2: 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4.2: 19 h / 20 °C

5.1: palladium diacetate; potassium carbonate; XPhos / tert-butyl alcohol / 3 h / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 20 °C

7.1: hydrogenchloride / diethyl ether; dichloromethane / 20 °C

With hydrogenchloride; Benzoyl bromide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; palladium diacetate; sodium hydride; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; XPhos; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; 5.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2017.02.001

Reference yield:

: tert-butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate

: 1342949-34-1
N-(3,4-difluorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

2.1: Benzoyl bromide; 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 12 h / 20 °C

2.2: 2 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3.2: 19 h / 20 °C

4.1: palladium diacetate; potassium carbonate; XPhos / tert-butyl alcohol / 3 h / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 20 °C

6.1: hydrogenchloride / diethyl ether; dichloromethane / 20 °C

With hydrogenchloride; Benzoyl bromide; tetrabutyl ammonium fluoride; palladium diacetate; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; XPhos; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; 4.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2017.02.001