Technology Process of Carbamic acid, [6-(bromomethyl)-2-methoxy-3-pyridinyl]-, phenylmethyl
ester
There total 1 articles about Carbamic acid, [6-(bromomethyl)-2-methoxy-3-pyridinyl]-, phenylmethyl
ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
tetrachloromethane;
for 18h;
Heating;
DOI:10.1021/jo010712n
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 37 percent / tetrahydrofuran; diethyl ether / 0 - 50 °C
2: (DHQD)2-AQN; K3Fe(CN)6; K2CO3 / OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 23 °C
3: 82 percent / 4-(dimethylamino)pyridine; Et3N / CH2Cl2 / 19 h / 23 °C
4: 75 percent / 2,6-lutidine / CH2Cl2 / 1 h / -78 - 23 °C
5: 0.95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 23 °C
6: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 2 h / -78 °C
7: 0.134 g / KMnO4; NaH2PO4 / H2O; 2-methyl-propan-2-ol / 0.08 h / 23 °C
With
2,6-dimethylpyridine; dmap; potassium permanganate; sodium dihydrogenphosphate; oxalyl dichloride; (DHQD)2AQN; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III);
osmium(VIII) oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; tert-butyl alcohol;
6: Swern oxidation;
DOI:10.1021/jo010712n
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 37 percent / tetrahydrofuran; diethyl ether / 0 - 50 °C
2: (DHQD)2-AQN; K3Fe(CN)6; K2CO3 / OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 23 °C
3: 82 percent / 4-(dimethylamino)pyridine; Et3N / CH2Cl2 / 19 h / 23 °C
4: 75 percent / 2,6-lutidine / CH2Cl2 / 1 h / -78 - 23 °C
5: 0.95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 23 °C
6: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 2 h / -78 °C
With
2,6-dimethylpyridine; dmap; oxalyl dichloride; (DHQD)2AQN; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III);
osmium(VIII) oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; tert-butyl alcohol;
6: Swern oxidation;
DOI:10.1021/jo010712n
