Technology Process of Carbamic acid, [(3S)-3-formyl-1,2,3,5-tetrahydro-5-oxo-6-indolizinyl]-,
phenylmethyl ester
There total 7 articles about Carbamic acid, [(3S)-3-formyl-1,2,3,5-tetrahydro-5-oxo-6-indolizinyl]-,
phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 ℃;
for 2h;
DOI:10.1021/jo010712n
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 12 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 18 h / Heating
2: 37 percent / tetrahydrofuran; diethyl ether / 0 - 50 °C
3: (DHQD)2-AQN; K3Fe(CN)6; K2CO3 / OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 23 °C
4: 82 percent / 4-(dimethylamino)pyridine; Et3N / CH2Cl2 / 19 h / 23 °C
5: 75 percent / 2,6-lutidine / CH2Cl2 / 1 h / -78 - 23 °C
6: 0.95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 23 °C
7: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 2 h / -78 °C
With
2,6-dimethylpyridine; dmap; N-Bromosuccinimide; oxalyl dichloride; (DHQD)2AQN; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III); dibenzoyl peroxide;
osmium(VIII) oxide;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; tert-butyl alcohol;
7: Swern oxidation;
DOI:10.1021/jo010712n
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 37 percent / tetrahydrofuran; diethyl ether / 0 - 50 °C
2: (DHQD)2-AQN; K3Fe(CN)6; K2CO3 / OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 23 °C
3: 82 percent / 4-(dimethylamino)pyridine; Et3N / CH2Cl2 / 19 h / 23 °C
4: 75 percent / 2,6-lutidine / CH2Cl2 / 1 h / -78 - 23 °C
5: 0.95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 23 °C
6: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 2 h / -78 °C
With
2,6-dimethylpyridine; dmap; oxalyl dichloride; (DHQD)2AQN; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III);
osmium(VIII) oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; tert-butyl alcohol;
6: Swern oxidation;
DOI:10.1021/jo010712n
