Technology Process of 3-Indolizinecarboxylic acid,
1,2,3,5-tetrahydro-5-oxo-6-[[(phenylmethoxy)carbonyl]amino]-, (3S)-
There total 9 articles about 3-Indolizinecarboxylic acid,
1,2,3,5-tetrahydro-5-oxo-6-[[(phenylmethoxy)carbonyl]amino]-, (3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium dihydrogenphosphate; NaClO2; acetic acid; triethylamine;
In
methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
- Guidance literature:
-
With
potassium permanganate; sodium dihydrogenphosphate;
In
water; tert-butyl alcohol;
at 23 ℃;
for 0.0833333h;
DOI:10.1021/jo010712n
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 12 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 18 h / Heating
2: 37 percent / tetrahydrofuran; diethyl ether / 0 - 50 °C
3: (DHQD)2-AQN; K3Fe(CN)6; K2CO3 / OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 23 °C
4: 82 percent / 4-(dimethylamino)pyridine; Et3N / CH2Cl2 / 19 h / 23 °C
5: 75 percent / 2,6-lutidine / CH2Cl2 / 1 h / -78 - 23 °C
6: 0.95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 23 °C
7: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 2 h / -78 °C
8: 0.134 g / KMnO4; NaH2PO4 / H2O; 2-methyl-propan-2-ol / 0.08 h / 23 °C
With
2,6-dimethylpyridine; dmap; potassium permanganate; sodium dihydrogenphosphate; N-Bromosuccinimide; oxalyl dichloride; (DHQD)2AQN; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III); dibenzoyl peroxide;
osmium(VIII) oxide;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; tert-butyl alcohol;
7: Swern oxidation;
DOI:10.1021/jo010712n
