2-Chloro-5-(2-methoxyphenyl)-1,3,4-thiadiazole

Base Information

Chemical Name:2-Chloro-5-(2-methoxyphenyl)-1,3,4-thiadiazole
CAS No.:40288-19-5
Molecular Formula:C9H7ClN2OS
Molecular Weight:226.686
Hs Code.:
DSSTox Substance ID:DTXSID001248560
Mol file:40288-19-5.mol

Synonyms:2-chloro-5-(2-methoxyphenyl)-1,3,4-thiadiazole;40288-19-5;DTXSID001248560;AKOS012692381;CS-0240229;EN300-226914;Z1136468465

Suppliers and Price of 2-Chloro-5-(2-methoxyphenyl)-1,3,4-thiadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-Chloro-5-(2-methoxyphenyl)-1,3,4-thiadiazole

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:225.9967617
Heavy Atom Count:14
Complexity:196

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1C2=NN=C(S2)Cl

Technology Process of 2-Chloro-5-(2-methoxyphenyl)-1,3,4-thiadiazole

There total 2 articles about 2-Chloro-5-(2-methoxyphenyl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28004-56-0
2-amino-5-(o-methoxyphenyl)-1,3,4-thiadiazole

: 40288-19-5
2-Chloro-5-(2-methoxy-phenyl)-[1,3,4]thiadiazole

Guidance literature:: With hydrogenchloride; copper; acetic acid; sodium nitrite; at 15 - 20 ℃; for 4h;
DOI:10.1021/jm00400a003

Reference yield:

: 4334-73-0,497161-86-1
2-[(2-methoxyhenyl)methylene]hydrazinecarbothioamide

: 40288-19-5
2-Chloro-5-(2-methoxy-phenyl)-[1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: FeCl₃*6H₂O / ethanol / 2 h / Heating

2: conc. HCl, aq. NaNO₂, copper, glacial acetic acid / 4 h / 15 - 20 °C

With hydrogenchloride; iron(III) chloride; copper; acetic acid; sodium nitrite; In ethanol;
DOI:10.1021/jm00400a003