Carbamic acid, [5-[[2-[bis(2-pyridinylmethyl)amino]ethyl](phenylmethyl)amino]-3-oxopent yl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [5-[[2-[bis(2-pyridinylmethyl)amino]ethyl](phenylmethyl)amino]-3-oxopent yl]-, 1,1-dimethylethyl ester
• CAS No.: 402921-70-4
• Molecular Formula: C31H41N5O3
• Molecular Weight: 531.698
• Mol file: 402921-70-4.mol

Synonyms:

Chemical Property of Carbamic acid, [5-[[2-[bis(2-pyridinylmethyl)amino]ethyl](phenylmethyl)amino]-3-oxopent yl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [5-[[2-[bis(2-pyridinylmethyl)amino]ethyl](phenylmethyl)amino]-3-oxopent yl]-, 1,1-dimethylethyl ester

There total 10 articles about Carbamic acid, [5-[[2-[bis(2-pyridinylmethyl)amino]ethyl](phenylmethyl)amino]-3-oxopent yl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3-oxopent-4-enyl)carbamic acid tert-butyl ester (402921-69-1) + N-benzyl-N’,N’-bis(2-pyridylmethyl)-1,2-diaminoethane (402921-64-6) → (5-{benzyl[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-32-oxopentyl)carbamic acid tert-butyl ester (402921-70-4)

Guidance literature:

In methanol; at 20 ℃; for 24h;

DOI:10.1039/b103164n

Reference yield:

(2-aminoethyl)bis(2-pyridylmethyl)amine (189440-33-3) → (5-{benzyl[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-32-oxopentyl)carbamic acid tert-butyl ester (402921-70-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / MgSO₄ / CH₂Cl₂ / 3 h / 20 °C

2: 91 percent / NaBH₄ / acetonitrile; acetic acid; ethanol / 18 h / 20 °C

3: 97 percent / methanol / 24 h / 20 °C

With sodium tetrahydroborate; magnesium sulfate; In methanol; ethanol; dichloromethane; acetic acid; acetonitrile; 3: Michael addition;

DOI:10.1039/b103164n

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → (5-{benzyl[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-32-oxopentyl)carbamic acid tert-butyl ester (402921-70-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 100 percent / MgSO₄ / CH₂Cl₂ / 3 h / 20 °C

2: 73 percent / NaBH₄ / acetonitrile; ethanol; acetic acid / 18 h / 20 °C

3: 68 percent / K₂CO₃; KI / acetonitrile / 24 h / Heating

4: 68 percent / hydrazine monohydrate / ethanol / 3 h / Heating

5: 100 percent / MgSO₄ / CH₂Cl₂ / 3 h / 20 °C

6: 91 percent / NaBH₄ / acetonitrile; acetic acid; ethanol / 18 h / 20 °C

7: 97 percent / methanol / 24 h / 20 °C

With sodium tetrahydroborate; magnesium sulfate; potassium carbonate; hydrazine hydrate; potassium iodide; In methanol; ethanol; dichloromethane; acetic acid; acetonitrile; 7: Michael addition;

DOI:10.1039/b103164n

upstream raw materials:

(3-oxopent-4-enyl)carbamic acid tert-butyl ester

N-benzyl-N’,N’-bis(2-pyridylmethyl)-1,2-diaminoethane

pyridine-2-carbaldehyde

2-(Aminomethyl)pyridine

Downstream raw materials:

1-amino-5-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}pentan-32-ol

1-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-5-[(3-methyl-3H-imidazol-4-ylmrthylene)amino]pentan-3-ol

2-[(5-{benzyl-[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-3-hydroxypentylimino)methyl]phenol