4-Chloro-1H-indazol-3-amine

Base Information

• Chemical Name: 4-Chloro-1H-indazol-3-amine
• CAS No.: 20925-60-4
• Molecular Formula: C7H6ClN3
• Molecular Weight: 167.598
• Hs Code.: 29339900
• Mol file: 20925-60-4.mol

Synonyms:3-Amino-4-chloro-1H-indazole; 3-amino-4-chloroindazole; 4-chloro-1H-indazole-3-amine; 1H-Indazol-3-amine,4-chloro; 4-Chlor-3-amino-1H-indazol; 4-Chlor-3-amino-indazol; 查看更多英文别名 收起

Chemical Property of 4-Chloro-1H-indazol-3-amine

Chemical Property:

• Vapor Pressure: 6.86E-07mmHg at 25°C
• Melting Point: 159-162 °C
• Refractive Index: 1.777
• Boiling Point: 408.7 °C at 760 mmHg
• PKA: 13.72±0.40(Predicted)
• Flash Point: 201 °C
• PSA: 54.70000
• Density: 1.533 g/cm³
• LogP: 2.37970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-1H-indazol-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

Useful:

Technology Process of 4-Chloro-1H-indazol-3-amine

There total 6 articles about 4-Chloro-1H-indazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-6-hydrazinobenzonitrile (914311-51-6) → 3-amino-4-chloro-1H-indazole (20925-60-4)

Guidance literature:

In tetrahydrofuran; at 75 ℃; for 1h;

DOI:10.1021/jo0613784

Reference yield: 74.0%

2,6-dichloro-benzonitrile (1194-65-6) → 3-amino-4-chloro-1H-indazole (20925-60-4)

Guidance literature:

With pyridine; sodium acetate; hydrazine hydrate; at 100 - 105 ℃;

DOI:10.1021/op900208y

Reference yield: 66.0%

2-chloro-6-fluorobenzonitrile (668-45-1) → 3-amino-4-chloro-1H-indazole (20925-60-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 3.5h; Inert atmosphere;

upstream raw materials:

2-chloro-6-hydrazinobenzonitrile

2-chloro-6-fluorobenzonitrile

2-chloro-6-fluorobenzaldehyde

2,6-dichloro-benzonitrile

Downstream raw materials:

linifanib

3-[(3-amino-4-chloro-1H-indazol-1-yl)methyl]benzonitrile