5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide

Base Information

Chemical Name:5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide
CAS No.:1240518-36-8
Molecular Formula:C₁₉H₁₂Cl₂N₄O₂S₂
Molecular Weight:463.368
Hs Code.:

Synonyms:5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide

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Chemical Property of 5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide

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Technology Process of 5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide

There total 4 articles about 5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 2766-74-7
5-chlorothien-2-ylsulfonyl chloride

: 1240518-32-4
3-[(3-amino-4-fluoro-1H-indazol-1-yl)methyl]benzonitrile

: 1240518-36-8
5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide

Guidance literature:: With pyridine; at 20 ℃;

Reference yield: 29.0%

: 2766-74-7
5-chlorothien-2-ylsulfonyl chloride

: 1240518-35-7
3-[(3-amino-4-chloro-1H-indazol-1-yl)methyl]benzonitrile

: 1240518-36-8
5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm301572h

Reference yield:

: 20925-60-4
3-amino-4-chloro-1H-indazole

: 1240518-36-8
5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

1.2: 2 h

2.1: pyridine / 0.5 h / 20 °C / Inert atmosphere

With pyridine; potassium hydroxide; In dimethyl sulfoxide;
DOI:10.1021/jm301572h