N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

Base Information

Chemical Name:N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide
CAS No.:1240518-78-8
Molecular Formula:C₁₉H₁₆Cl₂N₄O₂S₂
Molecular Weight:467.4
Hs Code.:

Synonyms:N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

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Chemical Property of N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

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Technology Process of N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

There total 3 articles about N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240518-36-8
5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide

: 1240518-78-8
N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

Guidance literature:: 5-chloro-N-{4-chloro-1-[(3-cyanophenyl)methyl]-1H-indazol-3-yl}-2-thiophenesulfonamide; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere; Cooling with ice;

With water; In tetrahydrofuran; diethyl ether;

Reference yield:

: 20925-60-4
3-amino-4-chloro-1H-indazole

: 1240518-78-8
N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

1.2: 2 h

2.1: pyridine / 0.5 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 45 h / 10 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/jm301572h

Reference yield:

: 668-45-1
2-chloro-6-fluorobenzonitrile

: 1240518-78-8
N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 3.5 h / 90 °C / Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

2.2: 2 h

3.1: pyridine / 0.5 h / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 45 h / 10 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm301572h