6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE

Base Information

• Chemical Name: 6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE
• CAS No.: 24048-74-6
• Molecular Formula: C6H6 N2 O3
• Molecular Weight: 154.125
• Hs Code.: 2933599090
• Mol file: 24048-74-6.mol

Synonyms:5-Pyrimidinecarboxaldehyde,2,4-dihydroxy-6-methyl- (6CI); 1,2,3,4-Tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinecarbaldehyde;5-Formyl-6-methyluracil; NSC 301171

Chemical Property of 6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE

Chemical Property:

• PKA: 8.33±0.10(Predicted)
• PSA: 83.05000
• Density: 1.435g/cm³
• LogP: -0.40360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE

There total 5 articles about 6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-hydroxymethyl-6-methyluracil (147-61-5) → 1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinecarbaldehyde (24048-74-6)

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In water; 1.) 90-100 deg C; 2.) room temp. 16 h;

DOI:10.1021/jo00329a027

Reference yield:

6-Methyluracil (626-48-2) → 1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinecarbaldehyde (24048-74-6)

Guidance literature:

nach Reimer-Tiemann;

DOI:10.1111/0002-9092.00141

Reference yield:

6-Methyluracil (626-48-2) → 1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinecarbaldehyde (24048-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / aq. NaOH / H₂O / 40 h / 25 °C

2: 60 percent / ceric ammonium nitrate / H₂O / 25 °C

With sodium hydroxide; ammonium cerium(IV) nitrate; In water;

DOI:10.1021/jo00208a022

upstream raw materials:

6-Methyluracil

5-hydroxymethyl-6-methyluracil

Downstream raw materials:

Ethyl (E)-3-(2,4-Dioxo-6-methyl-5-pyrimidinyl)acrylate

2,4-dioxo-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile

5-bromo-6-methyluracil

5-chloro-6-methyluracil

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