4-Nitrophenyl N2,N6-bis((phenylmethoxy)carbonyl)-L-lysinate

Base Information

• Chemical Name: 4-Nitrophenyl N2,N6-bis((phenylmethoxy)carbonyl)-L-lysinate
• CAS No.: 21160-82-7
• Molecular Formula: C28H29N3O8
• Molecular Weight: 535.554
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID00943483
• Wikidata: Q82920580
• Mol file: 21160-82-7.mol

Synonyms:EINECS 244-251-6;DTXSID00943483;4-Nitrophenyl N2,N6-bis((phenylmethoxy)carbonyl)-L-lysinate;4-Nitrophenyl N-[(benzyloxy)carbonyl]-N-(4-{[(benzyloxy)(hydroxy)methylidene]amino}butyl)glycinate

Chemical Property of 4-Nitrophenyl N2,N6-bis((phenylmethoxy)carbonyl)-L-lysinate

Chemical Property:

• Vapor Pressure: 1.55E-21mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 713.5 °C at 760 mmHg
• PKA: 10.61±0.46(Predicted)
• Flash Point: 385.3 °C
• PSA: 148.78000
• Density: 1.289 g/cm³
• LogP: 6.19690
• Storage Temp.: 2-8°C
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 15
• Exact Mass: 535.19546489
• Heavy Atom Count: 39
• Complexity: 769

Purity/Quality:

97% ^*data from raw suppliers

Z-LYS(Z)-ONP ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCCCCN(CC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])C(=O)OCC3=CC=CC=C3

Technology Process of 4-Nitrophenyl N2,N6-bis((phenylmethoxy)carbonyl)-L-lysinate

There total 2 articles about 4-Nitrophenyl N2,N6-bis((phenylmethoxy)carbonyl)-L-lysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine (405-39-0) → 4-nitrophenyl N2,N6-bis[(phenylmethoxy)carbonyl]-L-lysinate (21160-82-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate;

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + N(α),N(ε)-Dibenzyloxycarbonyl-L-lysin → 4-nitrophenyl N2,N6-bis[(phenylmethoxy)carbonyl]-L-lysinate (21160-82-7)

Guidance literature:

Multistep reaction; (i) MgSO₄, aq. HCl, AcOEt, (ii) /BRN= 1281877/, DCC, CH₂Cl₂;

Reference yield: 96.0%

4-nitrophenyl N2,N6-bis[(phenylmethoxy)carbonyl]-L-lysinate (21160-82-7) + acetone oxime (127-06-0) → Nα,Nε-dibenzyloxycarbonyl L-lysine acetoxime ester

Guidance literature:

In chloroform; Ambient temperature;

DOI:10.1016/S0040-4020(01)81345-4

upstream raw materials:

4-nitro-phenol

N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine

Downstream raw materials:

N^α,N^ε-Bis-(benzyloxycarbonyl)-Lys-ε-aminocaproyl-Phe-methylester

(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid

N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine

(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid