4-hydroxy-7-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one

Base Information

Chemical Name:4-hydroxy-7-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one
CAS No.:69884-05-5
Molecular Formula:C9H9NO4
Molecular Weight:195.175
Hs Code.:
UNII:TLH8Y7KQK2
DSSTox Substance ID:DTXSID00220160
Nikkaji Number:J67.848A
Wikidata:Q83097280
ChEMBL ID:CHEMBL2269102

Synonyms:69884-05-5;4-hydroxy-7-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one;4-hydroxy-7-methoxy-1,4-benzoxazin-3-one;2H-1,4-BENZOXAZIN-3(4H)-ONE,4-HYDROXY-7-METHOXY;4-Hydroxy-7-methoxy-1,4-benzoxazinone;BRN 4315641;4-Hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one;TLH8Y7KQK2;2H-1,4-Benzoxazin-3(4H)-one, 4-hydroxy-7-methoxy-;MOHB;UNII-TLH8Y7KQK2;CHEMBL2269102;DTXSID00220160;AKOS025393341;LS-42010;CS-0454977;7-methoxy-4-hydroxy-2h-1,4-benzoxazin-3-one;HYDROXY-7-METHOXY-1,4-BENZOXAZINONE, 4-;4-Hydroxy-7-methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one

Suppliers and Price of 4-hydroxy-7-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-hydroxy-7-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one

Chemical Property:

Vapor Pressure:8.22E-07mmHg at 25°C
Boiling Point:390.9°Cat760mmHg
Flash Point:190.2°C
Density:1.436g/cm³
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:195.05315777
Heavy Atom Count:14
Complexity:233

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)N(C(=O)CO2)O

Technology Process of 4-hydroxy-7-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one

There total 4 articles about 4-hydroxy-7-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 157067-43-1
ethyl 5-methoxy-2-nitrophenoxyacetate

: 69884-05-5
4-hydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one

Guidance literature:: With sodium tetrahydroborate; palladium on activated charcoal; In 1,4-dioxane; water;
DOI:10.1021/jf062709g

Reference yield: 64.0%

: 131761-75-6
(5-Methoxy-2-nitro-phenoxy)-acetic acid methyl ester

: 69884-05-5
4-hydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one

Guidance literature:: With sodium tetrahydroborate; palladium on activated charcoal; In 1,4-dioxane; water; at 15 - 20 ℃;
DOI:10.1021/jo00005a025

Reference yield:

: 704-14-3
3-methoxy-6-nitro-phenol

: 69884-05-5
4-hydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: KOH / ethanol / 1 h

1.2: 99 percent / dimethylformamide / 24 h

2.1: 70 percent / NaBH₄ / Pd/C / H₂O; dioxane

With potassium hydroxide; sodium tetrahydroborate; palladium on activated charcoal; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jf062709g