3-(3-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-(3-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER
• CAS No.: 40640-97-9
• Molecular Formula: C11H13BrO2
• Molecular Weight: 257.127
• Hs Code.: 2916399090
• Mol file: 40640-97-9.mol

Synonyms:Benzenepropanoic acid,3-bromo-,ethyl ester;

Chemical Property of 3-(3-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 303.398oC at 760 mmHg
• Flash Point: 137.29oC
• PSA: 26.30000
• Density: 1.343g/cm3
• LogP: 2.94480
• Storage Temp.: 2-8°C

Purity/Quality:

98.0% ^*data from raw suppliers

Ethyl3-(3-bromophenyl)propanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER

There total 8 articles about 3-(3-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 3-(3-bromophenyl)propanoic acid (42287-90-1) → ethyl 3-(3-bromophenyl)propanoate (40640-97-9)

Guidance literature:

3-(3-bromophenyl)propanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h;

ethanol; In dichloromethane; at -10 - 20 ℃; for 4h;

Reference yield: 100.0%

ethanol (64-17-5) → ethyl 3-(3-bromophenyl)propanoate (40640-97-9)

Guidance literature:

3-(3-bromophenyl)propanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h;

ethanol; In dichloromethane; at -10 - 25 ℃; for 4h;

Reference yield: 100.0%

ethyl 3-bromo-cinnamate (24398-80-9) → ethyl 3-(3-bromophenyl)propanoate (40640-97-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 16h;

DOI:10.1021/acschembio.0c00146

upstream raw materials:

1,3-dibromobenzene

ethyl acrylate

acrylaldehyde diethyl acetal

1-Bromo-3-iodobenzene

Downstream raw materials:

3-(3-bromophenyl)-propan-1-ol

ethyl 3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]-propionate

C₂₇H₂₄F₃NO₄

3-(3-furan-2-yl-phenyl)-propionic acid ethyl ester

Refernces

• 1、 Nakashima, Ken-Ichi,Yamaguchi, Eiji,Noritake, Chihaya,Mitsugi, Yukari,Goto, Mayuki,Hirai, Takao,Abe, Naohito,Sakai, Eiji,Oyama, Masayoshi,Itoh, Akichika,Inoue, Makoto. "Discovery and SAR of Natural-Product-Inspired RXR Agonists with Heterodimer Selectivity to PPARδ-RXR". . p. 1526 - 1534. Retrieved 2020/05/19.
• 2、 Desai, Janish,Wang, Yang,Wang, Ke,Malwal, Satish R.,Oldfield, Eric. "Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth". . p. 2205 - 2215. Retrieved 2016/10/22.