Tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate
CAS No.:412357-32-5
Molecular Formula:C18H22N2O4
Molecular Weight:330.37800
Hs Code.:2933399090
DSSTox Substance ID:DTXSID90476755
Wikidata:Q82308534
Mol file:412357-32-5.mol

Synonyms:412357-32-5;tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate;tert-butyl 4-(1,3-dioxoisoindol-2-yl)piperidine-1-carboxylate;tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-1-carboxylate;tert-butyl 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-1-carboxylate;SCHEMBL1029343;DTXSID90476755;LGBJBNFDEVHLKN-UHFFFAOYSA-N;FT-0707563;A850606;J-524577;2-(1-tert-butoxycarbonyl-4-piperidyl)isoindoline-1,3-dione;2-(1-tert-butoxycarbonyl-4-piperidyl)-isoindoline-1,3-dione

Suppliers and Price of Tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate 95+%
1g
$ 1186.00

Chemenu
tert-butyl4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate 95%
1g
$ 1118.00

American Custom Chemicals Corporation
TERT-BUTYL-4-(1,3-DIOXOISOINDOLIN-2-YL)PIPERIDINE-1-CARBOXYLATE 95.00%
5MG
$ 501.62

Alichem
tert-Butyl4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate
1g
$ 979.20

Total 12 raw suppliers

Chemical Property of Tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate

Chemical Property:

PSA：66.92000
LogP:2.55790
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:330.15795719
Heavy Atom Count:24
Complexity:508

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)N2C(=O)C3=CC=CC=C3C2=O

Technology Process of Tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate

There total 6 articles about Tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 136918-14-4,85-41-6
phthalimide

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 412357-32-5
tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate

Guidance literature:: phthalimide; t-butyl 4-hydroxy piperidine-1-carboxylate; With di-isopropyl azodicarboxylate; 4-(Me₃SiCH₂CH₂OCO)C₆H₄-PPh₂; In tetrahydrofuran; at 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1055/s-2003-37520

Reference yield: 36.0%

: 1074-82-4
potassium phtalimide

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 412357-32-5
tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 16h;

Reference yield:

: 85-44-9
phthalic anhydride

: 108-24-7
acetic anhydride

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 412357-32-5
tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate

Guidance literature:: phthalic anhydride; 1-(tert-butoxycarbonyl)-4-aminopiperidine; With hydrazine; In toluene;

acetic anhydride; In toluene; at 90 - 95 ℃;