4-(Benzyloxy)-1,2-diMethoxybenzene

Base Information

• Chemical Name: 4-(Benzyloxy)-1,2-diMethoxybenzene
• CAS No.: 42138-42-1
• Molecular Formula: C15H16O3
• Molecular Weight: 244.29
• Mol file: 42138-42-1.mol

Synonyms:

Chemical Property of 4-(Benzyloxy)-1,2-diMethoxybenzene

Chemical Property:

• Vapor Pressure: 3.89E-05mmHg at 25°C

Purity/Quality:

98%Min ^*data from raw suppliers

4-(Benzyloxy)-1,2-dimethoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Benzyloxy)-1,2-dimethoxybenzene is used in the preparation of Thalicarpine, a tumor-inhibitory aporphine benzylisoquinoline alkaloid.

Technology Process of 4-(Benzyloxy)-1,2-diMethoxybenzene

There total 5 articles about 4-(Benzyloxy)-1,2-diMethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-dimethoxyphenol (2033-89-8) + benzyl bromide (100-39-0) → 1,2-dimethoxy-4-(benzyloxy)benzene (42138-42-1)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2007.09.032

Reference yield:

3,4-dimethoxyphenol (2033-89-8) + benzyl chloride (100-44-7) → 1,2-dimethoxy-4-(benzyloxy)benzene (42138-42-1)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja00790a044

Reference yield:

methoxyhydroquinone (824-46-4) → 1,2-dimethoxy-4-(benzyloxy)benzene (42138-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.2 g / K₂CO₃ / dimethylformamide / 1.5 h / 160 - 165 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jo01290a003

upstream raw materials:

diazomethane

4-(benzyloxy)-2-methoxyphenol

3,4-dimethoxyphenol

benzyl chloride

Downstream raw materials:

2-benzyloxy-4,5-dimethoxy-benzaldehyde

3,4-dimethoxyphenol

2-benzyl-4,5-dimethoxyphenol

(1R,8aS)-1-(2-(benzyloxy)-4,5-dimethoxybenzyl)-5,5,8a-trimethyloctahydronaphthalen-2(1H)-one