2-BENZYLOXY-4,5-DIMETHOXYBENZALDEHYDE

Base Information

• Chemical Name: 2-BENZYLOXY-4,5-DIMETHOXYBENZALDEHYDE
• CAS No.: 14382-86-6
• Molecular Formula: C16H16O4
• Molecular Weight: 272.301
• Hs Code.: 2912499000
• Mol file: 14382-86-6.mol

Synonyms:Benzaldehyde,2-(benzyloxy)-4,5-dimethoxy- (8CI);2-Benzyloxy-4,5-dimethoxybenzaldehyde;

Chemical Property of 2-BENZYLOXY-4,5-DIMETHOXYBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 4.8E-08mmHg at 25°C
• Melting Point: 138-141 °C(lit.)
• Refractive Index: 1.577
• Boiling Point: 443 °C at 760 mmHg
• Flash Point: 197.5 °C
• PSA: 44.76000
• Density: 1.164 g/cm³
• LogP: 3.09530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

2-Benzyloxy-4,5-dimethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-BENZYLOXY-4,5-DIMETHOXYBENZALDEHYDE

There total 9 articles about 2-BENZYLOXY-4,5-DIMETHOXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2-dimethoxy-4-(benzyloxy)benzene (42138-42-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-benzyloxy-4,5-dimethoxy-benzaldehyde (14382-86-6)

Guidance literature:

1,2-dimethoxy-4-(benzyloxy)benzene; N,N-dimethyl-formamide; With trichlorophosphate; at 100 ℃; for 0.333333h;

With water; at 60 ℃; for 0.166667h; Further stages.;

DOI:10.1021/jo800467e

Reference yield: 83.0%

2-hydroxy-4,5-dimethoxybenzaldehyde (14382-91-3) + benzyl bromide (100-39-0) → 2-benzyloxy-4,5-dimethoxy-benzaldehyde (14382-86-6)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 40 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.10.034

Reference yield: 83.0%

→ 2-benzyloxy-4,5-dimethoxy-benzaldehyde (14382-86-6)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 40 ℃; for 12h; Inert atmosphere;

upstream raw materials:

1,2-dimethoxy-4-(benzyloxy)benzene

N,N-dimethyl-formamide

Dichloromethyl methyl ether

3,4-dimethoxyphenyl acetate

Downstream raw materials:

1-(2-Benzyloxy-4,5-dimethoxy-phenyl)-2-nitro-ethanol

2-Benzyloxy-4,5-dimethoxyphenylessigsaeure

2-Benzyloxy-4,5-dimethoxybenzylcyanid

2'-hydroxy-7,4',5'-trimethoxyflavone

Refernces

• 1、 Jang, Ha Young,Park, Hyeong Jin,Damodar, Kongara,Kim, Jin-Kyung,Jun, Jong-Gab. "Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents". . p. 5438 - 5443. Retrieved 2016/11/09.
• 2、 Liermann, Johannes C.,Opatz, Till. "Synthesis of lamellarin U and lamellarin G trimethyl ether by alkylation of a deprotonated α-aminonitrile". . p. 4526 - 4531. Retrieved 2008/09/21.