1,3-Dicyclohexylbarbituric acid

Base Information

Chemical Name:1,3-Dicyclohexylbarbituric acid
CAS No.:35824-91-0
Molecular Formula:C16H24 N2 O3
Molecular Weight:292.378
Hs Code.:2933540000
DSSTox Substance ID:DTXSID30957235
Nikkaji Number:J501.933H
Wikidata:Q82937507
ChEMBL ID:CHEMBL1766835
Mol file:35824-91-0.mol

Synonyms:1,3-Dicyclohexylbarbituric acid;35824-91-0;1,3-dicyclohexyl-1,3-diazinane-2,4,6-trione;1,3-dicyclohexylpyrimidine-2,4,6(1H,3H,5H)-trione;BRN 0893954;BARBITURIC ACID, 1,3-DICYCLOHEXYL-;MFCD01216967;1,3-dicyclohexyl-2,4,6(1H,3H,5H)-pyrimidinetrione;5-24-09-00094 (Beilstein Handbook Reference);LCZC2833;SCHEMBL3422430;CHEMBL1766835;DTXSID30957235;AKOS005228461;AS-60573;LS-24136;SY053752;CS-0451621;D2815;N16905;J-503898

Suppliers and Price of 1,3-Dicyclohexylbarbituric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N,N''-DicyclohexylbarbituricAcid
50mg
$ 145.00

TRC
N,N''-DicyclohexylbarbituricAcid
500mg
$ 1035.00

TRC
N,N''-DicyclohexylbarbituricAcid
250mg
$ 640.00

American Custom Chemicals Corporation
1,3-DICYCLOHEXYL-2,4,6(1H,3H,5H)PYRIMIDINETRIONE 95.00%
5MG
$ 503.12

AK Scientific
1,3-Dicyclohexylbarbituricacid
10g
$ 502.00

Total 25 raw suppliers

Chemical Property of 1,3-Dicyclohexylbarbituric acid

Chemical Property:

Vapor Pressure:4.68E-07mmHg at 25°C
Melting Point:203 °C
Boiling Point:413.8°C at 760 mmHg
PKA:6.09±0.40(Predicted)
Flash Point:172.9°C
PSA：57.69000
Density:1.226g/cm³
LogP:2.70850
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:292.17869263
Heavy Atom Count:21
Complexity:399

Purity/Quality:

99% ^*data from raw suppliers

N,N''-DicyclohexylbarbituricAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)N2C(=O)CC(=O)N(C2=O)C3CCCCC3
Uses N,N''-Dicyclohexylbarbituric Acid is an intermediate in the synthesis of Daprodustat (D193368), which is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.

Technology Process of 1,3-Dicyclohexylbarbituric acid

There total 11 articles about 1,3-Dicyclohexylbarbituric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 116418-82-7
1,3-dicyclohexyl-5-diazopyrimidine-2,4,6(1H,3H,5H)-trione

: 128961-28-4
1,3-Dicyclohexyl-2,4-dioxo-imidazolin-5-carbonsaeureethylester

: 35824-91-0
1,3-dicyclohexyl barbituric acid

Guidance literature:: With ethanol; Irradiation;

Reference yield: 87.0%

: 141-82-2
malonic acid

: 538-75-0
dicyclohexyl-carbodiimide

: 35824-91-0
1,3-dicyclohexyl barbituric acid

Guidance literature:: With trichlorophosphate; In tetrahydrofuran; at 80 ℃; for 0.06h; Reagent/catalyst; Temperature; Concentration; Mechanism; Flow reactor;
DOI:10.1021/acs.oprd.7b00375